Pentanoic acid, 4-[(2,3-dichlorobenzoyl)amino]-5-[(3,3-dimethylbutyl)amino]-5-oxo-, (R)-

Base Information

• Chemical Name: Pentanoic acid, 4-[(2,3-dichlorobenzoyl)amino]-5-[(3,3-dimethylbutyl)amino]-5-oxo-, (R)-
• CAS No.: 137795-23-4
• Molecular Formula: C18H24Cl2N2O4
• Molecular Weight: 403.306
• Mol file: 137795-23-4.mol

Synonyms:

Chemical Property of Pentanoic acid, 4-[(2,3-dichlorobenzoyl)amino]-5-[(3,3-dimethylbutyl)amino]-5-oxo-, (R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Pentanoic acid, 4-[(2,3-dichlorobenzoyl)amino]-5-[(3,3-dimethylbutyl)amino]-5-oxo-, (R)-

There total 4 articles about Pentanoic acid, 4-[(2,3-dichlorobenzoyl)amino]-5-[(3,3-dimethylbutyl)amino]-5-oxo-, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,3-dimethylbutylamine (15673-00-4) → (R)-4-(2,3-Dichloro-benzoylamino)-4-(3,3-dimethyl-butylcarbamoyl)-butyric acid (137795-23-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) triethylamine, ethyl chloroformate / 1.) THF, -10 deg C, 15 min, 2.)a) THF, -10 deg C, 1 h, b) RT, 3 h

2: 81 percent / H₂, H₂O / 10percent Pd/activated charcoal / methanol / 2 h / 760 Torr / Ambient temperature

3: aq. NaOH / tetrahydrofuran / 3 h / Ambient temperature

With sodium hydroxide; water; hydrogen; chloroformic acid ethyl ester; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1021/jm00079a003

Reference yield:

(2R)-5-(benzyloxy)-2-{[(benzyloxy)carbonyl]amino}-5-oxopentanoic acid (59486-73-6) → (R)-4-(2,3-Dichloro-benzoylamino)-4-(3,3-dimethyl-butylcarbamoyl)-butyric acid (137795-23-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) triethylamine, ethyl chloroformate / 1.) THF, -10 deg C, 15 min, 2.)a) THF, -10 deg C, 1 h, b) RT, 3 h

2: 81 percent / H₂, H₂O / 10percent Pd/activated charcoal / methanol / 2 h / 760 Torr / Ambient temperature

3: aq. NaOH / tetrahydrofuran / 3 h / Ambient temperature

With sodium hydroxide; water; hydrogen; chloroformic acid ethyl ester; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1021/jm00079a003

Reference yield:

(R)-4-<(carbobenzyloxy)amino>-5-<(3,3-dimethylbutyl)amino>-5-oxopentanoic acid, benzyl ester (136269-78-8) → (R)-4-(2,3-Dichloro-benzoylamino)-4-(3,3-dimethyl-butylcarbamoyl)-butyric acid (137795-23-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / H₂, H₂O / 10percent Pd/activated charcoal / methanol / 2 h / 760 Torr / Ambient temperature

2: aq. NaOH / tetrahydrofuran / 3 h / Ambient temperature

With sodium hydroxide; water; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1021/jm00079a003

upstream raw materials:

2,3-dichlorobenzoyl chloride

(R)-4-amino-5-<3,3-dimethylbutyl)amino>-5-oxopentanoic acid

3,3-dimethylbutylamine

(2R)-5-(benzyloxy)-2-{[(benzyloxy)carbonyl]amino}-5-oxopentanoic acid