15673-00-4Relevant articles and documents
Catalysis by Cucurbituril. The Significance of Bound-Substrate Destabilization for Induced Triazole Formation
Mock, William L.,Irra, Ted A.,Wepsiec, James P.,Adhya, Mita
, p. 5302 - 5308 (1989)
A mechanistic investigation is described for the cycloaddition induced between RNH2+CH2CCH and RNH2+CH2CH2N3 (R = H, t-Bu) consequent to encapsulationby the polycyclic molecular receptor cucrbituril (C36H36N24O12).The reaction is shown to be substantially accelerated (ca. 105-fold), and the kinetic characteristics of catalytic saturation behavior, substrate inhibition, and slow product release are documented.For substrates with R = t-Bu a rotaxane product results, and inhibition kinetics with NH3+CH2CH2C(CH3)3 are also examined.A rate enhancementattributed to bound-substrate destabilization is detected.The significance of this effect and its connection with the phenomenon of nonproductive binding in catalytic systems are discussed.
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Hecht,S.M. et al.
, p. 1907 - 1913 (1970)
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A new quadruply bound heterodimer DDAD·AADA and investigations into the association process
Brammer, Stefan,Luening, Ulrich,Kuehl, Christine
, p. 4054 - 4062 (2007/10/03)
DDAD·AADA heterodimers based on the structures 8 and 9 have been synthesised and characterised. Solubility problems have been overcome through the introduction of a 2,6-dimethylphenyl substituent (8c), and association constants Kass have been determined by 1H NMR titrations. The Kass values obtained could be confirmed by osmometry, as could the association constants for other heterodimers. The Kass value increases when the acidity of participating N-H hydrogen atoms is enhanced. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.
Sympathetic nervous system blocking agents. V. Derivatives of isobutyl-, t-butyl-, and neopentylguanidine.
Short,Ours,Ranus Jr.
, p. 1129 - 1135 (2007/10/05)
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