1,4-BENZENEDICARBONYL DICHLORIDE,2-BROMO-

Base Information

• Chemical Name: 1,4-BENZENEDICARBONYL DICHLORIDE,2-BROMO-
• CAS No.: 13815-89-9
• Molecular Formula: C8H3BrCl2O2
• Molecular Weight: 281.921
• Hs Code.: 2917399090
• Mol file: 13815-89-9.mol

Synonyms:3-bromoterephthaloyl chloride;1,4-Benzenedicarbonyl dichloride,2-bromo;2-bromoterephthaloyl dichloride;bromo-terephthaloyl chloride;2-bromoterephthaloyl chloride;Brom-terephthaloylchlorid;

Chemical Property of 1,4-BENZENEDICARBONYL DICHLORIDE,2-BROMO-

Chemical Property:

• Boiling Point: 158 °C(Press: 11 Torr)
• PSA: 34.14000
• Density: 1.779±0.06 g/cm3(Predicted)
• LogP: 3.20710

Purity/Quality:

99.90% ^*data from raw suppliers

1,4-BENZENEDICARBONYLDICHLORIDE,2-BROMO- 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4-BENZENEDICARBONYL DICHLORIDE,2-BROMO-

There total 3 articles about 1,4-BENZENEDICARBONYL DICHLORIDE,2-BROMO- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.8%

2-bromo-1,4-benzenedicarboxylic acid (586-35-6) → 2-bromobenzene-1,4-dicarbonyl dichloride (13815-89-9)

Guidance literature:

With thionyl chloride; In N,N-dimethyl-formamide; Heating;

Reference yield:

4-bromo-m-xylene (553-94-6) → 2-bromobenzene-1,4-dicarbonyl dichloride (13815-89-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium permanganate / water; tert-butyl alcohol / 12 h / 70 °C

2: thionyl chloride / 5 h / 100 °C

With potassium permanganate; thionyl chloride; In water; tert-butyl alcohol;

DOI:10.1021/jm2012408

Reference yield:

3-bromo-4-methylbenzoic acid (7697-26-9) → 2-bromobenzene-1,4-dicarbonyl dichloride (13815-89-9)

Guidance literature:

Multi-step reaction with 2 steps

1: permanganate

2: PCl₅

With phosphorus pentachloride; permanganate(VII) ion;

upstream raw materials:

2-bromo-1,4-benzenedicarboxylic acid

3-bromo-4-methylbenzoic acid

4-bromo-m-xylene

Downstream raw materials:

1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborole-6-carbaldehyde

(E)-[3-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)-1-phenyl]propenone

(E)-[3-(biphenyl-4-yl)-1-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)]propenone

3-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)-1-phenyl-propanone

Refernces

• 1、 Haynes, Keith M.,Abdali, Narges,Jhawar, Varsha,Zgurskaya, Helen I.,Parks, Jerry M.,Green, Adam T.,Baudry, Jerome,Rybenkov, Valentin V.,Smith, Jeremy C.,Walker, John K.. "Identification and Structure-Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli". . p. 6205 - 6219. Retrieved 2017/08/02.
• 2、 Butkevich, Alexey N.,Mitronova, Gyuzel Yu.,Sidenstein, Sven C.,Klocke, Jessica L.,Kamin, Dirk,Meineke, Dirk N. H.,D'Este, Elisa,Kraemer, Philip-Tobias,Danzl, Johann G.,Belov, Vladimir N.,Hell, Stefan W.. "Fluorescent Rhodamines and Fluorogenic Carbopyronines for Super-Resolution STED Microscopy in Living Cells". supporting information. p. 3290 - 3294. Retrieved 2016/03/22.