586-35-6Relevant articles and documents
SUBSTITUTED TRICYCLIC COMPOUNDS
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Page/Page column 171-172, (2021/07/02)
Disclosed are compounds of the general formula (I), its tautomeric form, its stereoisomer, its pharmaceutically acceptable salt, its polymorph, or solvate thereof, wherein, ring A, ring B, R1 to R4, and n are as defined herein, for use as SOS1 inhibitors in the treatment of proliferative, infectious and RASopathy diseases or disorders. Also disclosed are methods of synthesizing the compound of formula I, pharmaceutical compositions containing the compound of formula I, method of treatment of proliferative, infectious and RASopathy diseases or disorder, for example, a cancer, by administering the said compound and combinations of the compound of formula I with other active ingredients.
Continuous synthesis method for substituted benzoic acid organic matter
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Paragraph 0117-0119; 0138, (2019/10/01)
The invention provides a continuous synthesis method for a substituted benzoic acid organic matter. The continuous synthesis method comprises the following steps: in the presence of a catalyst and anorganic solvent, continuously putting an organic matter of a formula (I) shown in the specification, and oxygen into a continuous reaction device, carrying out a continuous oxidation reaction so as toobtain the substituted benzoic acid organic matter, and continuously discharging the substituted benzoic acid organic matter, wherein the substituted benzoic acid organic matter is of a structure ofa formula (II) shown in the specification. Oxygen is a green reagent and is cheap and easy to obtain, a great amount of wastes are not generated after reactions are completed, and the system is easy to treat. Due to continuous reaction operation, the risk that the solvent has flash evaporation explosion because of high-concentration oxygen in in-batch reactions can be reduced. Under same oxidationconditions, due to a continuous preparation process, escape of oxygen can be reduced, the utilization rate of oxygen can be greatly increased, operation can be also simplified, the security of reactions can be improved, and the yield of the substituted benzoic acid organic matter can be increased.
Structural diversity, luminescence and photocatalytic properties of six coordination polymers based on designed bifunctional 2-(imidazol-1-yl)terephthalic acid
Zhang, Xiutang,Fan, Liming,Fan, Weiliu,Li, Bin,Liu, Guangzeng,Liu, Xinzheng,Zhao, Xian
, p. 6914 - 6925 (2016/09/23)
Six coordination polymers (CPs), {[M(ITA)]·0.5H2O}n (M = Zn 1, M = Mn 2), {[Zn(ITA)(bib)0.5]·1.5H2O}n (3), {[Ni(ITA)(bib)0.5(H2O)3]·H2O}n (4), {[Zn(ITA)(bimb)0.5]·0.5H2O}n (5) and [Cd(ITA)(bimb)0.5(H2O)2]n (6), have been derived from the designed bifunctional 2-(imidazol-1-yl)terephthalic acid (H2ITA) with or without bis(imidazole) linkers (bib = 1,4-bis(imidazol-1-yl)benzene, bimb = 1,4-bis(imidazol-1-ylmethyl)benzene). X-Ray single-crystal diffraction analysis reveals that complexes 1 and 2 are isomorphic with the same 3D (4)-connected {4·63·82} net. Complex 3 features a 3D 2-fold interpenetrated (3,4)-connected fsc net with point symbol of {4·82·103}{4·82}. Complex 4 displays a 2D 3-connected {63)-hcb sheet, which can be further expanded into a 3D supramolecular network through hydrogen bonding interactions. Complex 5 exhibits an unprecedented 3D 2-fold interpenetrated (3,4)-connected dmc net with point symbol of {4·82}{4·85}. Complex 6 shows a 3D (3,4)-connected {4·82·103}{4·82}-fsc net. Structural comparison reveals that not only the coordination preferences of metal ions but also the auxiliary bis(imidazole) linkers play crucial roles in the control of the final structures. Besides, the photoluminescence properties as well as the photocatalytic activities for the degradation of methylene blue (MB) under UV-vis light of 1, 3, 5 and 6 have been investigated.
