L-Phenylalaninamide, N-[(phenylmethoxy)carbonyl]-N-propyl-L-tyrosyl-D-methionylglycyl-N-[6-[( 6-methoxy-6-oxohexyl)amino]-6-oxohexyl]-

Base Information

Chemical Name:L-Phenylalaninamide, N-[(phenylmethoxy)carbonyl]-N-propyl-L-tyrosyl-D-methionylglycyl-N-[6-[( 6-methoxy-6-oxohexyl)amino]-6-oxohexyl]-
CAS No.:138199-80-1
Molecular Formula:C49H68N6O10S
Molecular Weight:933.179
Hs Code.:
Mol file:138199-80-1.mol

L-Phenylalaninamide,
N-[(phenylmethoxy)carbonyl]-N-propyl-L-tyrosyl-D-methionylglycyl-N-[6-[(
6-methoxy-6-oxohexyl)amino]-6-oxohexyl]-

Synonyms:

Suppliers and Price of L-Phenylalaninamide, N-[(phenylmethoxy)carbonyl]-N-propyl-L-tyrosyl-D-methionylglycyl-N-[6-[( 6-methoxy-6-oxohexyl)amino]-6-oxohexyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of L-Phenylalaninamide, N-[(phenylmethoxy)carbonyl]-N-propyl-L-tyrosyl-D-methionylglycyl-N-[6-[( 6-methoxy-6-oxohexyl)amino]-6-oxohexyl]-

Chemical Property:

Purity/Quality:

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Technology Process of L-Phenylalaninamide, N-[(phenylmethoxy)carbonyl]-N-propyl-L-tyrosyl-D-methionylglycyl-N-[6-[( 6-methoxy-6-oxohexyl)amino]-6-oxohexyl]-

There total 13 articles about L-Phenylalaninamide, N-[(phenylmethoxy)carbonyl]-N-propyl-L-tyrosyl-D-methionylglycyl-N-[6-[( 6-methoxy-6-oxohexyl)amino]-6-oxohexyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: (R)-2-[(S)-2-(Benzyloxycarbonyl-propyl-amino)-3-(4-hydroxy-phenyl)-propionylamino]-4-methylsulfanyl-butyric acid

: 6-{6-[(S)-2-(2-Amino-acetylamino)-3-phenyl-propionylamino]-hexanoylamino}-hexanoic acid methyl ester; hydrochloride

: 138199-80-1
Z-PrTyr-D-Met-Gly-Phe-εAhx-εAhx-OMe

Guidance literature:: With TEA; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; 1.) 0 deg C, 2.) RT, overnight;

Reference yield:

: 6404-29-1
6-(tert-butoxycarbonylamino)hexanoic acid

: 138199-80-1
Z-PrTyr-D-Met-Gly-Phe-εAhx-εAhx-OMe

Guidance literature:: Multi-step reaction with 7 steps

1: 40 percent / TEA, HOBt, DCCI / CH₂Cl₂ / 1.) 0 deg C, 2.) RT, overnight

2: HCl / dioxane / 0.5 h / Ambient temperature

3: 82 percent / TEA, HOBt, DCCI / CH₂Cl₂ / 1.) 0 deg C, 2.) RT, overnight

4: HCl / dioxane / 0.5 h / Ambient temperature

5: 71 percent / TEA, HOBt, DCCI / CH₂Cl₂ / 1.) 0 deg C, 2.) RT, overnight

6: HCl / dioxane / 0.5 h / Ambient temperature

7: 82 percent / TEA, HOBt, DCCI / CH₂Cl₂ / 1.) 0 deg C, 2.) RT, overnight

With hydrogenchloride; TEA; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane;

Reference yield:

: 1164-16-5
Z-L-Tyr-OH

: 138199-80-1
Z-PrTyr-D-Met-Gly-Phe-εAhx-εAhx-OMe

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / NaH / tetrahydrofuran / 18 h / Ambient temperature

2: 82 percent / TEA, HOBt, DCCI / CH₂Cl₂ / 1.) 0 deg C, 2.) RT, overnight

3: aq. NaOH / methanol

4: 82 percent / TEA, HOBt, DCCI / CH₂Cl₂ / 1.) 0 deg C, 2.) RT, overnight

With sodium hydroxide; TEA; sodium hydride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane;