1H-Pyrrole-3-carboxylic acid, 5-(4-chlorophenyl)-2-methyl-1-[4-[1-[3-(trifluoromethyl)phenyl]-1H-imidaz ol-4-yl]phenyl]-, ethyl ester

Base Information

Chemical Name:1H-Pyrrole-3-carboxylic acid, 5-(4-chlorophenyl)-2-methyl-1-[4-[1-[3-(trifluoromethyl)phenyl]-1H-imidaz ol-4-yl]phenyl]-, ethyl ester
CAS No.:138225-94-2
Molecular Formula:C30H23ClF3N3O2
Molecular Weight:549.98
Hs Code.:
Mol file:138225-94-2.mol

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Chemical Property of 1H-Pyrrole-3-carboxylic acid, 5-(4-chlorophenyl)-2-methyl-1-[4-[1-[3-(trifluoromethyl)phenyl]-1H-imidaz ol-4-yl]phenyl]-, ethyl ester

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Technology Process of 1H-Pyrrole-3-carboxylic acid, 5-(4-chlorophenyl)-2-methyl-1-[4-[1-[3-(trifluoromethyl)phenyl]-1H-imidaz ol-4-yl]phenyl]-, ethyl ester

There total 2 articles about 1H-Pyrrole-3-carboxylic acid, 5-(4-chlorophenyl)-2-methyl-1-[4-[1-[3-(trifluoromethyl)phenyl]-1H-imidaz ol-4-yl]phenyl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 111787-82-7
2-[2-(4-chlorophenyl)-2-oxo-ethyl]-3-oxo-butyric acid ethyl ester

: 138225-80-6
4-[1-(3-Trifluoromethyl-phenyl)-1H-imidazol-4-yl]-phenylamine

: 138225-94-2
5-(4-Chloro-phenyl)-2-methyl-1-{4-[1-(3-trifluoromethyl-phenyl)-1H-imidazol-4-yl]-phenyl}-1H-pyrrole-3-carboxylic acid ethyl ester

Guidance literature:: With hydrogen bromide; In ethanol; for 3h; Heating;

Reference yield:

: 114660-51-4
4-(4-Nitro-phenyl)-1-(3-trifluoromethyl-phenyl)-1H-imidazole

: 138225-94-2
5-(4-Chloro-phenyl)-2-methyl-1-{4-[1-(3-trifluoromethyl-phenyl)-1H-imidazol-4-yl]-phenyl}-1H-pyrrole-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / calcium chloride, powdered iron / aq. ethanol / 3 h / Heating

2: 80 percent / HBr / ethanol / 3 h / Heating

With hydrogen bromide; iron; calcium chloride; In ethanol;