Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-5-methyl-

Base Information

• Chemical Name: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-5-methyl-
• CAS No.: 138239-62-0
• Molecular Formula: C31H32N2O8
• Molecular Weight: 560.604
• Mol file: 138239-62-0.mol

Synonyms:1-(5-O-(bis(4-methoxyphenyl)phenylmethyl)-β-D-ribofuranosyl)-5-methyl-1-1H,3H-pyrimidine-2,4-dione;1-[5-O-(bis(4-methoxyphenyl)phenylmethyl)-β-D-ribofuranosyl]-5-methyl-1-1H,3H-pyrimidine-2,4-dione;5'-O-(4,4'-dimethoxytrityl)-5-methyluridine;1-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;

Chemical Property of Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-5-methyl-

Chemical Property:

• PSA: 132.24000
• Density: 1.319±0.06 g/cm3(Predicted)
• LogP: 2.49010

Purity/Quality:

97% ^*data from raw suppliers

5'-O-DMT-5-methyluridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-5-methyl-

There total 6 articles about Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-5-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + 5-Methyluridine (1463-10-1,642082-80-2) → 1-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (138239-62-0)

Guidance literature:

With pyridine; at 20 ℃;

DOI:10.1039/d1ob01174j

Reference yield:

2,4-dimethoxytrityl chloride (861355-55-7) + (2R,3R,4R,5R)-2-(acetoxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate (4336-39-4,4645-02-7) → 1-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (138239-62-0)

Guidance literature:

In pyridine; Inert atmosphere;

Reference yield:

2',3',5'-tri-O-benzoyluridine (3180-76-5) → 1-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (138239-62-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / NaOMe / methanol / 24 h / Ambient temperature

2: 71 percent / pyridine / 1.25 h / Ambient temperature

With pyridine; sodium methylate; In methanol;

DOI:10.1002/jhet.5570300522

upstream raw materials:

4,4'-dimethoxytrityl chloride

5-Methyluridine

2',3',5'-tri-O-benzoyluridine

thymin

Downstream raw materials:

3-(2-cyanoethyl)-1-<5-O--β-D-ribofuranosyl>-5-methyl-1-1H,3H-pyrimidine-2,4-dione

5'-O-(4,4'-dimethoxytrityl)-5-methyl-2'-O-{[(triisopropylsilyl)oxy]methyl}uridine

5'-O-(4,4'-dimethoxytrityl)-5-methyl-2'-O-{[(triisopropylsilyl)oxy]methyl}cytidine

N⁴-acetyl-5'-O-(4,4'-dimethoxytrityl)-5-methyl-2'-O-{[(triisopropylsilyl)oxy]methyl}cytidine