2,6-DIMETHYL-4-IODOANILINE

Base Information

• Chemical Name: 2,6-DIMETHYL-4-IODOANILINE
• CAS No.: 138385-59-8
• Molecular Formula: C8H10IN.ClH
• Molecular Weight: 283.54
• Hs Code.: 2921430090
• Mol file: 138385-59-8.mol

Synonyms:4-iodo-2,6-dimethylbenzeneamine hydrochloride;4-iodo-2,6-dimethylbenzenamine hydrochloride;4-iodo-2,6-dimethylbenzeneamine hydrochloride salt;4-Iodo-2,6-dimethyl-phenylamine hydrochloride;4-Iodo-2,6-dimethylaniline hydrochloride;2,5-DIMETHOXY-N-(2-THIENYLMETHYL)ANILINE;QC-8677;

Chemical Property of 2,6-DIMETHYL-4-IODOANILINE

Chemical Property:

• Vapor Pressure: 0.00204mmHg at 25°C
• PSA: 26.02000
• LogP: 3.87340
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: Methanol

Purity/Quality:

97% ^*data from raw suppliers

2,6-Dimethyl-4-iodoaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,6-Dimethyl-4-iodoaniline (cas# 138385-59-8) is a compound useful in organic synthesis.

Technology Process of 2,6-DIMETHYL-4-IODOANILINE

There total 2 articles about 2,6-DIMETHYL-4-IODOANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2,6-dimethylaniline (87-62-7) → 4-iodo-2,6-dimethylbenzenamine hydrochloride (138385-59-8)

Guidance literature:

2,6-dimethylaniline; With Iodine monochloride; sodium hydrogencarbonate; In methanol; dichloromethane; at 20 ℃; for 4h;

With hydrogenchloride; In diethyl ether; water;

Reference yield:

4-iodo-2,6-dimethylaniline (4102-53-8) → 4-iodo-2,6-dimethylbenzenamine hydrochloride (138385-59-8)

Guidance literature:

With hydrogenchloride; In diethyl ether; Inert atmosphere;

DOI:10.1021/jm800546t

Reference yield:

methyl 2-(benzyloxycarbonyl)acrylate (116280-25-2) + 4-iodo-2,6-dimethylbenzenamine hydrochloride (138385-59-8) → (Z)-methyl 3-(4-amino-3,5-dimethylphenyl)-2-(benzyloxycarbonyl)acrylate (1337918-86-1) + (E)-methyl 3-(4-amino-3,5-dimethylphenyl)-2-(benzyloxycarbonyl)acrylate

Guidance literature:

With tetrabutyl-ammonium chloride; triethylamine; palladium diacetate; In tetrahydrofuran; for 3h; Reflux;

upstream raw materials:

4-iodo-2,6-dimethylaniline

2,6-dimethylaniline

Downstream raw materials:

1,4-diiodo-2,6-dimethylbenzene

2-[(4-Iodo-2,6-dimethyl-phenyl)-hydrazono]-malononitrile

2-iodo-5-(dicyanomethyl)-1,3-dimethylbenzene

(R)-methyl 2-(((benzyloxy)carbonyl)amino)-3-(7-methyl-1H-indazol-5-yl)propanoate