(R)-methyl 2-(((benzyloxy)carbonyl)amino)-3-(7-methyl-1H-indazol-5-yl)propanoate

Base Information

• Chemical Name: (R)-methyl 2-(((benzyloxy)carbonyl)amino)-3-(7-methyl-1H-indazol-5-yl)propanoate
• CAS No.: 855778-40-4
• Molecular Formula: C₂₀H₂₁N₃O₄
• Molecular Weight: 367.404
• Mol file: 855778-40-4.mol

Synonyms:(R)-methyl 2-(((benzyloxy)carbonyl)amino)-3-(7-methyl-1H-indazol-5-yl)propanoate

Chemical Property of (R)-methyl 2-(((benzyloxy)carbonyl)amino)-3-(7-methyl-1H-indazol-5-yl)propanoate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-methyl 2-(((benzyloxy)carbonyl)amino)-3-(7-methyl-1H-indazol-5-yl)propanoate

There total 11 articles about (R)-methyl 2-(((benzyloxy)carbonyl)amino)-3-(7-methyl-1H-indazol-5-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

(R)-methyl 3-(4-amino-3,5-dimethylphenyl)-2-(benzyloxycarbonyl)propanoate (855778-39-1) → (R)-methyl 2-(((benzyloxy)carbonyl)amino)-3-(7-methyl-1H-indazol-5-yl)propanoate (855778-40-4)

Guidance literature:

(R)-methyl 3-(4-amino-3,5-dimethylphenyl)-2-(benzyloxycarbonyl)propanoate; With acetic acid; In toluene; at 20 ℃; for 0.166667h;

With potassium acetate; isopentyl nitrite; In toluene; at 20 ℃; for 16h;

With sodium hydrogencarbonate; In water; toluene;

Reference yield: 76.0%

(R)-methyl 3-(4-amino-3,5-dimethylphenyl)-2-(benzyloxycarbonyl)propanoate (1337918-87-2) → (R)-methyl 2-(((benzyloxy)carbonyl)amino)-3-(7-methyl-1H-indazol-5-yl)propanoate (855778-40-4)

Guidance literature:

With potassium acetate; acetic acid; isopentyl nitrite; In toluene; at 20 ℃; for 16h;

Reference yield: 73.0%

methyl (R)-3-(4-amino-3,5-dimethylphenyl)-2-(benzyloxycarbonylamino)-propanoate methanesulfonate (1414976-13-8) → (R)-methyl 2-(((benzyloxy)carbonyl)amino)-3-(7-methyl-1H-indazol-5-yl)propanoate (855778-40-4)

Guidance literature:

With potassium carbonate; In water; ethyl acetate; at 20 ℃; for 0.666667h; Further stages; Large scale;

DOI:10.1021/op3003097

upstream raw materials:

(R)-methyl 3-(4-amino-3,5-dimethylphenyl)-2-(benzyloxycarbonyl)propanoate

2,6-dimethylaniline

4-iodo-2,6-dimethylbenzenamine hydrochloride

(Z)-methyl 3-(4-amino-3,5-dimethylphenyl)-2-(benzyloxycarbonyl)acrylate

Downstream raw materials:

(R)-2-(benzyloxycarbonylamino)-3-(7-methyl-1H-indazol-5-yl)propanoic acid