Propanoic acid, 2-methyl-, 1-phenylethyl ester, (R)-

Base Information

• Chemical Name: Propanoic acid, 2-methyl-, 1-phenylethyl ester, (R)-
• CAS No.: 138457-64-4
• Molecular Formula: C12H16O2
• Molecular Weight: 192.258
• Mol file: 138457-64-4.mol

Synonyms:

Chemical Property of Propanoic acid, 2-methyl-, 1-phenylethyl ester, (R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Propanoic acid, 2-methyl-, 1-phenylethyl ester, (R)-

There total 12 articles about Propanoic acid, 2-methyl-, 1-phenylethyl ester, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-nitrophenyl isobutyrate (4195-16-8) + 1-Phenylethanol (98-85-1,13323-81-4) → (1R)-1-phenylethyl 2-methylpropanoate (138457-64-4)

Guidance literature:

With dicarbonyl(chloro)(η⁵-pentaphenylcyclopentadienyl)ruthenium(II); (2S,3R)-3-isopropyl-2-phenyl-3,4-dihydro-2H-benzo[4,5]thiazolo[3,2-a]pyrimidine; potassium tert-butylate; potassium carbonate; at 20 ℃; for 72h; Reagent/catalyst; enantioselective reaction; Inert atmosphere;

DOI:10.1021/acs.joc.1c00545

Reference yield:

isobutyric acid 1-phenyl-ethyl ester (7775-39-5) → (R)-1-phenylethanol (1517-69-7) + (1R)-1-phenylethyl 2-methylpropanoate (138457-64-4) + (S)-1-phenylethyl 2-methylpropanoate (76149-13-8)

Guidance literature:

With sodium carbonate; In toluene; at 40 ℃; for 72h; Solvent; Reagent/catalyst; Temperature; enantioselective reaction; Enzymatic reaction;

DOI:10.1007/s10562-020-03525-0

Reference yield:

1-Phenylethanol (98-85-1,13323-81-4) + 2-Methylpropionic anhydride (97-72-3) → (S)-1-phenylethanol (1445-91-6) + (R)-1-phenylethanol (1517-69-7) + (1R)-1-phenylethyl 2-methylpropanoate (138457-64-4) + (S)-1-phenylethyl 2-methylpropanoate (76149-13-8)

Guidance literature:

With chiral 2-(3',5'-di-tert-butylphenyl)-4,4,8-trimethyl-2-phosphabicylo<3.3.0>octane; In n-heptane; for 1h; Product distribution; Ambient temperature; other catalyst; var. temp.; other carbinols;

DOI:10.1021/ja990133o

upstream raw materials:

1-Phenylethanol

2-Methylpropionic anhydride

vinyl isobutyrate

(R)-1-phenylethanol

Downstream raw materials:

(R)-1-phenylethanol