Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[1-(2-chloroeth oxy)ethyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

Base Information

Chemical Name:Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[1-(2-chloroeth oxy)ethyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
CAS No.:138494-31-2
Molecular Formula:C51H59ClN7O9P
Molecular Weight:980.498
Hs Code.:

Adenosine,
N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[1-(2-chloroeth
oxy)ethyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[1-(2-chloroeth oxy)ethyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

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Technology Process of Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[1-(2-chloroeth oxy)ethyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

There total 5 articles about Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[1-(2-chloroeth oxy)ethyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 138078-31-6
6-N-benzoyl-2'-O-(1-(2-chloroethoxy)ethyl)-5'-O-dimethoxytrityladenosine

: 138494-31-2
3'-O-<(2-cyanoethyl)(diisopropylamino)phosphino>-5'-O-dimethoxytrityl-2'-O-<1-(2-chloroethoxy)ethyl>-N⁶-benzoyladenosine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 1h; Ambient temperature;
DOI:10.1016/S0040-4020(01)96193-9

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 138494-31-2
3'-O-<(2-cyanoethyl)(diisopropylamino)phosphino>-5'-O-dimethoxytrityl-2'-O-<1-(2-chloroethoxy)ethyl>-N⁶-benzoyladenosine

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / pyridine

2: 87 percent / N,N-diisopropylethylamine / tetrahydrofuran / 1 h / Ambient temperature

With pyridine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
DOI:10.1016/S0040-4020(01)96193-9

Reference yield:

: 79154-57-7
3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-N₆-benzoyladenosine

: 138494-31-2
3'-O-<(2-cyanoethyl)(diisopropylamino)phosphino>-5'-O-dimethoxytrityl-2'-O-<1-(2-chloroethoxy)ethyl>-N⁶-benzoyladenosine

Guidance literature:: Multi-step reaction with 4 steps

1: pyridinium p-toluenesulfonate / CH₂Cl₂ / Ambient temperature

2: tetraethylammonium hydrogen fluoride / tetrahydrofuran / 1.5 h

3: 87 percent / pyridine

4: 87 percent / N,N-diisopropylethylamine / tetrahydrofuran / 1 h / Ambient temperature

With pyridine; pyridinium p-toluenesulfonate; tetraethylammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4020(01)96193-9