Benzaldehyde, 4-[[2,5-bis(acetyloxy)-4-methylphenyl]methyl]-

Base Information

• Chemical Name: Benzaldehyde, 4-[[2,5-bis(acetyloxy)-4-methylphenyl]methyl]-
• CAS No.: 138536-81-9
• Molecular Formula: C19H18O5
• Molecular Weight: 326.349
• Mol file: 138536-81-9.mol

Synonyms:

Chemical Property of Benzaldehyde, 4-[[2,5-bis(acetyloxy)-4-methylphenyl]methyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzaldehyde, 4-[[2,5-bis(acetyloxy)-4-methylphenyl]methyl]-

There total 8 articles about Benzaldehyde, 4-[[2,5-bis(acetyloxy)-4-methylphenyl]methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

acetic anhydride (108-24-7) + 4-(4-Methyl-3,6-dioxo-cyclohexa-1,4-dienylmethyl)-benzaldehyde → 4-<(2,5-diacetoxy-4-methylphenyl)methyl>benzaldehyde (138536-81-9)

Guidance literature:

With sodium acetate; zinc; at 0 ℃;

DOI:10.1246/bcsj.64.3005

Reference yield:

2,5-dimethoxy toluene (24599-58-4) → 4-<(2,5-diacetoxy-4-methylphenyl)methyl>benzaldehyde (138536-81-9)

Guidance literature:

Multi-step reaction with 7 steps

1: SnCl₄ / CH₂Cl₂ / Heating

2: 95 percent / KOH, hydrazine monohydrate / bis-(2-hydroxy-ethyl) ether / 5.5 h / 200 °C

3: 96 percent / potassium carbonate / acetone / Heating

4: 89 percent / LiAlH₄ / tetrahydrofuran / 6.5 h / 0 deg C to r.t.

5: 89 percent / pyridinium chlorochromate / CH₂Cl₂ / 3 h / Ambient temperature

6: 826 mg / cerium(IV) ammonium nitrate / acetonitrile; H₂O / 2 h

7: 96 percent / Zn dust, sodium acetate / 0 °C

With potassium hydroxide; lithium aluminium tetrahydride; ammonium cerium(IV) nitrate; sodium acetate; tin(IV) chloride; potassium carbonate; hydrazine hydrate; pyridinium chlorochromate; zinc; In tetrahydrofuran; dichloromethane; water; acetone; acetonitrile; diethylene glycol;

DOI:10.1246/bcsj.64.3005

Reference yield:

4-Methoxycarbonylbenzoyl chloride (7377-26-6) → 4-<(2,5-diacetoxy-4-methylphenyl)methyl>benzaldehyde (138536-81-9)

Guidance literature:

Multi-step reaction with 7 steps

1: SnCl₄ / CH₂Cl₂ / Heating

2: 95 percent / KOH, hydrazine monohydrate / bis-(2-hydroxy-ethyl) ether / 5.5 h / 200 °C

3: 96 percent / potassium carbonate / acetone / Heating

4: 89 percent / LiAlH₄ / tetrahydrofuran / 6.5 h / 0 deg C to r.t.

5: 89 percent / pyridinium chlorochromate / CH₂Cl₂ / 3 h / Ambient temperature

6: 826 mg / cerium(IV) ammonium nitrate / acetonitrile; H₂O / 2 h

7: 96 percent / Zn dust, sodium acetate / 0 °C

With potassium hydroxide; lithium aluminium tetrahydride; ammonium cerium(IV) nitrate; sodium acetate; tin(IV) chloride; potassium carbonate; hydrazine hydrate; pyridinium chlorochromate; zinc; In tetrahydrofuran; dichloromethane; water; acetone; acetonitrile; diethylene glycol;

DOI:10.1246/bcsj.64.3005

upstream raw materials:

acetic anhydride

2,5-dimethoxy toluene

4-Methoxycarbonylbenzoyl chloride

4-(2',5'-dimethoxy-4'-methylbenzyl)benzaldehyde

Downstream raw materials:

5-(4-methylphenyl)-15-<4-<(2,5-diacetoxy-4-methylphenyl)-methyl>phenyl>-2,8,12,18-tetrahexyl-3,7,13,17-tetramethylporphine

15-<2,6-bis(benzyloxy)phenyl>-15'-<4-<(2,5-diacetoxy-4-methylphenyl)methyl>phenyl>-5,5'-(1,4-phenylene)bis<2,8,12,18-tetrahexyl-3,7,13,17-tetramethylporphine>

C₁₄₆H₁₇₈N₈O₆

C₁₄₇H₁₈₀N₈O₆