7377-26-6

Basic information

• Product Name: Methyl 4-chlorocarbonylbenzoate
• Synonyms: METHYL 4-CHLOROFORMYLBENZOATE;METHYL 4-CHLOROCARBONYLBENZOATE;4-(CHLOROCARBONYL)-BENZOIC ACID METHYL ESTER;4-CHLOROFORMYLBENZOIC ACID METHYL ESTER;TEREPHTALEIC ACID MONOMETHYL ESTER CHLORIDE;TEREPHTHALIC ACID MONOMETHYL ESTER CHLORIDE;TIMTEC-BB SBB005801;TEREPHTALIC ACID MONOMETHYL ESTER CHLORIDE
• CAS NO: 7377-26-6
• Molecular Formula: C₉H₇ClO₃
• Molecular Weight: 198.6
• EINECS: 230-937-2
• Product Categories: APIs Intermediate;Benzoic acid
• Mol File: 7377-26-6.mol
• Article Data: 115

Chemical Properties

• Melting Point: 50-59 °C
• Boiling Point: 140 °C / 15mmHg
• Flash Point: 127.3 °C
• Appearance: Off-white to light yellow/Crystalline Powder
• Density: 1.3219 (rough estimate)
• Vapor Pressure: 0.00191mmHg at 25°C
• Refractive Index: 1.5230 (estimate)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: HYDROLYSIS
• Water Solubility: HYDROLYSIS
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: Methyl 4-chlorocarbonylbenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4-chlorocarbonylbenzoate(7377-26-6)
• EPA Substance Registry System: Methyl 4-chlorocarbonylbenzoate(7377-26-6)

Safety Data

• Hazard Codes: C
• Statements: 34-22
• Safety Statements: 24/25-45-36/37/39-26
• RIDADR: 3261
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: Ⅲ
• Hazardous Substances Data: 7377-26-6(Hazardous Substances Data)

Usage

Chemical Properties

slight yellow to white solid

Uses

4-(Chlorocarbonyl)benzoic Acid Methyl Ester, is a building block, that can be used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of benzophenone residues and also for the synthesis of novel novel bulky hydrophobic retinoids.

InChI:InChI=1/C9H7ClO3/c1-13-9(12)7-4-2-6(3-5-7)8(10)11/h2-5H,1H3

Upstream product

• 67-56-1 methanol 
• 100-20-9 terephthaloyl chloride 
• 4091-02-5 vinyl methyl terephthalate 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 17763-71-2 4-carbomethoxyphenyl triflate 
• 141-75-3 butyryl chloride 
• 1033699-81-8 N,N-dibutylterephthalamic acid methyl ester 
• 153849-46-8 4-methoxycarbonyl-N-methyl-N-phenylbenzamide 
• 3814-10-6 N-phenyl-p-carbomethoxybenzamide 
• 21928-11-0 methyl 4-(dimethylcarbamoyl)benzoate 
• 100-21-0 terephthalic acid 
• 1679-64-7 Monomethyl terephthalate 
• 1147550-11-5 ammonium thiocyanate 
• 17874-79-2 pyridine-2,5-dicarboxylic acid 5-methyl ester 

Downstream Products

• 20093-73-6 terephthalic acid-(2-acetyl-phenyl ester)-methyl ester 
• 6724-91-0 N,N'-hexanediyl-bis-terephthalamic acid dimethyl ester 
• 5611-81-4 1,4-bis[2-[[4-(methoxycarbonyl) benzoyl]oxy]ethyl] 1,4-benzenedicarboxylate 
• 27239-22-1 methyl bis(2-hydroxyethyl) terephthalate 
• 2225-04-9 O,O'-(ethane-1,2-diyl)dimethyl diterephthalate 
• 102810-33-3 N,N'-bis-(4-methoxycarbonylbenzoyl)-1,4-butanediamine 
• 855293-47-9 4-(2,4-dimethyl-benzoyl)-benzoic acid 
• 35776-96-6 4-(4'-methylbenzoyl)benzoic acid 
• 7333-86-0 N-octadecyl-terephthalamic acid methyl ester 
• 611-95-0 4-carboxybenzophenone 
• 173458-34-9 4-azidocarbonyl-benzoic acid methyl ester 
• 56893-25-5 methyl 4-(2-bromoacetyl)benzoate 
• 27884-94-2 N-{4-[Bis-(2-chloro-ethyl)-amino]-phenyl}-terephthalamic acid methyl ester 
• 21928-11-0 methyl 4-(dimethylcarbamoyl)benzoate 

Relevant articles and documents

Synthesis and fluorescence properties of environment-sensitive 7-(diethylamino)coumarin derivatives

By linking 7-(diethylamino)coumarin and different aromatic groups via an oxazole moiety, a small series of new environment-sensitive fluorophores have been synthesized. They display varying degrees of environment-sensitivity, depending on the aromatic gro

One-step Conversion of Amides and Esters to Acid Chlorides with PCl3

A general and efficient iodine-promoted chlorination of amides and esters with phosphorus trichloride is described. For the first time. Various inactivated amides including secondary and tertiary amides were directly converted to the corresponding acid chlorides in one-step. The substrate scope of methyl esters including aromatic and aliphatic esters was also explored under this system. This method is simple, scalable and wide in scope, which provides an approach to preparation of these acid chlorides.

sEH inhibitor and preparation method and application thereof

The invention provides an sEH inhibitor and a preparation method and application thereof, and relates to the technical field of endogenous active substance regulation and control. The sEH inhibitor provided by the invention has a structure as shown in a f

An efficient synthesis of a 6″-BODIPY-α-Galactosylceramide probe for monitoring α-Galactosylceramide uptake by cells

Herein, an efficient synthesis of BODIPY-α-Galactosylceramide 3, which can be used to study the cellular uptake of the potent immunostimulatory parent compound α-Galactosylceramide, is reported. Key in our synthetic strategy is the six-step synthesis of the core BODIPY scaffold (64% yield overall) and its quantitative conversion to an N-hydroxysuccinimidyl ester to facilitate conjugation and purification of the target glycolipid. For the preparation of the core of the glycolipid, the solubility of the lipid acceptor proved to be critical. The ability of BODIPY-αGalCer 3 to activate invariant natural killer cells was then demonstrated in vitro.