Cytidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[1-(2-chloroethoxy)ethyl]- N-(4-methoxybenzoyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

Base Information

Chemical Name:Cytidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[1-(2-chloroethoxy)ethyl]- N-(4-methoxybenzoyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
CAS No.:138603-22-2
Molecular Formula:C51H61ClN5O11P
Molecular Weight:986.499
Hs Code.:

Cytidine,
5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[1-(2-chloroethoxy)ethyl]-
N-(4-methoxybenzoyl)-, 3'-[2-cyanoethyl
bis(1-methylethyl)phosphoramidite]

Synonyms:

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Chemical Property of Cytidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[1-(2-chloroethoxy)ethyl]- N-(4-methoxybenzoyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

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Technology Process of Cytidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[1-(2-chloroethoxy)ethyl]- N-(4-methoxybenzoyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

There total 5 articles about Cytidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[1-(2-chloroethoxy)ethyl]- N-(4-methoxybenzoyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 138603-20-0
N-(1-{(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-[1-(2-chloro-ethoxy)-ethoxy]-4-hydroxy-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-4-methoxy-benzamide

: 138603-22-2
3'-O-<(2-cyanoethyl)(diisopropylamino)phosphino>-5'-O-dimethoxytrityl-2'-O-<1-(2-chloroethoxy)ethyl>-N⁴-anisoylcytidine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 1h; Ambient temperature;
DOI:10.1016/S0040-4020(01)96193-9

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 138603-22-2
3'-O-<(2-cyanoethyl)(diisopropylamino)phosphino>-5'-O-dimethoxytrityl-2'-O-<1-(2-chloroethoxy)ethyl>-N⁴-anisoylcytidine

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / pyridine

2: 82 percent / N,N-diisopropylethylamine / tetrahydrofuran / 1 h / Ambient temperature

With pyridine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
DOI:10.1016/S0040-4020(01)96193-9

Reference yield:

: 138494-29-8
N⁴-anisoyl-2'-O-<1-(2-chloroethoxy)ethyl>cytidine

: 138603-22-2
3'-O-<(2-cyanoethyl)(diisopropylamino)phosphino>-5'-O-dimethoxytrityl-2'-O-<1-(2-chloroethoxy)ethyl>-N⁴-anisoylcytidine

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / pyridine

2: 82 percent / N,N-diisopropylethylamine / tetrahydrofuran / 1 h / Ambient temperature

With pyridine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
DOI:10.1016/S0040-4020(01)96193-9