4-(2-Thienylmethyleneamino)salicylic acid

Base Information

• Chemical Name: 4-(2-Thienylmethyleneamino)salicylic acid
• CAS No.: 138712-94-4
• Molecular Formula: C12H9NO3S
• Molecular Weight: 247.274
• European Community (EC) Number: 666-057-4
• Mol file: 138712-94-4.mol

Synonyms:4-(2-THIENYLMETHYLENEAMINO)SALICYLIC ACID;AKOS024336528

Chemical Property of 4-(2-Thienylmethyleneamino)salicylic acid

Chemical Property:

• XLogP3: 3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 247.03031432
• Heavy Atom Count: 17
• Complexity: 308

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CSC(=C1)C=NC2=CC(=C(C=C2)C(=O)O)O

Technology Process of 4-(2-Thienylmethyleneamino)salicylic acid

There total 1 articles about 4-(2-Thienylmethyleneamino)salicylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

thiophene-2-carbaldehyde (98-03-3) + 4-Aminosalicylic acid (65-49-6) → 2-hydroxy-4(2-thenylidene)aminobenzoic acid (138712-94-4)

Guidance literature:

With triethylamine; In ethanol; for 6h; Heating;

Reference yield: 70.0%

2,4-bis(phenylthio)-1,3-dithia-2λ5,4λ5-diphosphetane 2,4-disulphide (60118-15-2,95591-54-1) + 2-hydroxy-4(2-thenylidene)aminobenzoic acid (138712-94-4) → 2-Phenylsulfanyl-7-{[1-thiophen-2-yl-meth-(E)-ylidene]-amino}-2-thioxo-2λ5-benzo[e][1,3,2]oxathiaphosphinine-4-thione (138713-00-5)

Guidance literature:

In toluene; at 110 ℃;

Reference yield: 60.0%

Lawessons reagent (19172-47-5,94367-93-8) + 2-hydroxy-4(2-thenylidene)aminobenzoic acid (138712-94-4) → 2-(4-Methoxy-phenyl)-7-{[1-thiophen-2-yl-meth-(E)-ylidene]-amino}-2-thioxo-2λ5-benzo[e][1,3,2]oxathiaphosphinine-4-thione (138712-99-9)

Guidance literature:

In toluene; at 110 ℃;

upstream raw materials:

thiophene-2-carbaldehyde

4-Aminosalicylic acid

Downstream raw materials:

2-(4-Methoxy-phenyl)-7-{[1-thiophen-2-yl-meth-(E)-ylidene]-amino}-2-thioxo-2λ⁵-benzo[e][1,3,2]oxathiaphosphinine-4-thione

2-Phenylsulfanyl-7-{[1-thiophen-2-yl-meth-(E)-ylidene]-amino}-2-thioxo-2λ⁵-benzo[e][1,3,2]oxathiaphosphinine-4-thione

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