2-Methyl-3-ethoxycarbonyl-4-(2'-trifluoromethylphenyl)-5-oxo-5,7-dihydrofuro(3,4-b)pyridine

Base Information

Chemical Name:2-Methyl-3-ethoxycarbonyl-4-(2'-trifluoromethylphenyl)-5-oxo-5,7-dihydrofuro(3,4-b)pyridine
CAS No.:126335-10-2
Molecular Formula:C₁₈H₁₄F₃NO₄
Molecular Weight:365.309
Hs Code.:
DSSTox Substance ID:DTXSID10155151
Wikidata:Q83022871

Synonyms:BRN 4272101;2-Methyl-3-ethoxycarbonyl-4-(2'-trifluoromethylphenyl)-5-oxo-5,7-dihydrofuro(3,4-b)pyridine;126335-10-2;Furo(3,4-b)pyridine-3-carboxylic acid, 5,7-dihydro-2-methyl-5-oxo-4-(2-(trifluoromethyl)phenyl)-, ethyl ester;SCHEMBL11008233;C18H14F3NO4;DTXSID10155151;XSJPBRPXKYNNNT-UHFFFAOYSA-N;C18-H14-F3-N-O4;LS-70884

Suppliers and Price of 2-Methyl-3-ethoxycarbonyl-4-(2'-trifluoromethylphenyl)-5-oxo-5,7-dihydrofuro(3,4-b)pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 2-Methyl-3-ethoxycarbonyl-4-(2'-trifluoromethylphenyl)-5-oxo-5,7-dihydrofuro(3,4-b)pyridine

Chemical Property:

Vapor Pressure:4.14E-11mmHg at 25°C
Boiling Point:524.9°Cat760mmHg
Flash Point:271.2°C
Density:1.359g/cm³
XLogP3:3.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:4
Exact Mass:365.08749241
Heavy Atom Count:26
Complexity:553

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=C(N=C2COC(=O)C2=C1C3=CC=CC=C3C(F)(F)F)C

Technology Process of 2-Methyl-3-ethoxycarbonyl-4-(2'-trifluoromethylphenyl)-5-oxo-5,7-dihydrofuro(3,4-b)pyridine

There total 2 articles about 2-Methyl-3-ethoxycarbonyl-4-(2'-trifluoromethylphenyl)-5-oxo-5,7-dihydrofuro(3,4-b)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 85615-21-0
ethyl 2-methyl-4-(2-trifluoromethylphenyl)-5-oxo-1,4-dihydro-5,7-dihydrofuro[3,4-b]pyridine-3-carboxylate

: 126335-10-2
2-methyl-3-ethoxycarbonyl-4-(2'-trifluoromethylphenyl)-5-oxo-5,7-dihydrofuro<3,4-b>pyridine

Guidance literature:: With nitric acid; at 70 - 80 ℃; for 1h;
DOI:10.1007/BF00764614

Reference yield:

: 23191-75-5
SKF 24260

: 126335-10-2
2-methyl-3-ethoxycarbonyl-4-(2'-trifluoromethylphenyl)-5-oxo-5,7-dihydrofuro<3,4-b>pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 42 percent / N-bromosuccinimide (NBS) / CHCl₃ / 0.5 h / Heating

2: 50 percent / 3 N nitric acid / 1 h / 70 - 80 °C

With N-Bromosuccinimide; nitric acid; In chloroform;
DOI:10.1007/BF00764614