Acetamide, N-(2,5-dimethoxyphenyl)-2,2,2-trifluoro-N-methyl-

Base Information

Chemical Name:Acetamide, N-(2,5-dimethoxyphenyl)-2,2,2-trifluoro-N-methyl-
CAS No.:138777-91-0
Molecular Formula:C₁₁H₁₂F₃NO₃
Molecular Weight:263.216
Hs Code.:
DSSTox Substance ID:DTXSID80445137
Wikidata:Q82263472
Mol file:138777-91-0.mol

Synonyms:138777-91-0;Acetamide, N-(2,5-dimethoxyphenyl)-2,2,2-trifluoro-N-methyl-;DTXSID80445137

Suppliers and Price of Acetamide, N-(2,5-dimethoxyphenyl)-2,2,2-trifluoro-N-methyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of Acetamide, N-(2,5-dimethoxyphenyl)-2,2,2-trifluoro-N-methyl-

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:263.07692773
Heavy Atom Count:18
Complexity:296

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(C1=C(C=CC(=C1)OC)OC)C(=O)C(F)(F)F

Technology Process of Acetamide, N-(2,5-dimethoxyphenyl)-2,2,2-trifluoro-N-methyl-

There total 5 articles about Acetamide, N-(2,5-dimethoxyphenyl)-2,2,2-trifluoro-N-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 10224-66-5
2,5-dimethoxy-N-methylaniline

: 407-25-0
trifluoroacetic anhydride

: 138777-91-0
N-(2',5'-dimethoxyphenyl)-2,2,2-trifluoro-N-methylacetamide

Guidance literature:: In chloroform; at 0 ℃; for 1h;

Reference yield:

: 138777-92-1
N-(2',5'-dimethoxyphenyl)-2,2,2-trifluoroacetamide

: 74-88-4
methyl iodide

: 138777-91-0
N-(2',5'-dimethoxyphenyl)-2,2,2-trifluoro-N-methylacetamide

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide;
DOI:10.7164/antibiotics.48.1460

Reference yield:

: 3467-59-2
2,5-dimethoxyacetanilide

: 138777-91-0
N-(2',5'-dimethoxyphenyl)-2,2,2-trifluoro-N-methylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / KOH / dimethylsulfoxide / 0.5 h / Ambient temperature

2: 98 percent / HCl / H₂O / 5 h / 100 °C

3: 74 percent / CHCl₃ / 1 h / 0 °C

With hydrogenchloride; potassium hydroxide; In chloroform; water; dimethyl sulfoxide;