3-(2,5,5-Trimethyl-1,3-dioxan-2-yl)-2-thiophenesulfonamide

Base Information

• Chemical Name: 3-(2,5,5-Trimethyl-1,3-dioxan-2-yl)-2-thiophenesulfonamide
• CAS No.: 138890-87-6
• Molecular Formula: C11H17NO4S2
• Molecular Weight: 291.38700
• Hs Code.: 2935009090
• Mol file: 138890-87-6.mol

Synonyms:3-(2,5,5-Trimethyl-1,3-dioxan-2-yl)-2-thiophenesulfonamide;3-(2,5,5-Trimethyl-1,3-dioxane-2-yl)-2-thiophenesulfonamide;3-(2,5,5-Trimethyl-1,3-dioxane-2-yl)-thiophene-2-sulfonamide;3-(2,5,5-Trimethyl-l,3-dioxane-2-yl)-2-thiophenesulfonamide;

Chemical Property of 3-(2,5,5-Trimethyl-1,3-dioxan-2-yl)-2-thiophenesulfonamide

Chemical Property:

• PSA: 115.24000
• Density: 1.278
• LogP: 3.42230
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

3-(2,5,5-Trimethyl-1,3-dioxan-2-yl)thiophene-2-sulfonamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2,5,5-Trimethyl-1,3-dioxan-2-yl)-2-thiophenesulfonamide

There total 2 articles about 3-(2,5,5-Trimethyl-1,3-dioxan-2-yl)-2-thiophenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3-(2,5,5-Trimethyl-l,3-dioxane-2-yl)thiophene (138890-86-5) → 3-(2,5,5-Trimethyl-1,3-dioxane-2-yl)-thiophene-2-sulfonamide (138890-87-6)

Guidance literature:

3-(2,5,5-Trimethyl-l,3-dioxane-2-yl)thiophene; With n-butyllithium; In hexane; at -60 - 20 ℃; for 3.25h; Inert atmosphere;

With sulfur dioxide; In tetrahydrofuran; hexane; at -65 - 20 ℃; Inert atmosphere;

With sodium acetate trihydrate; hydroxylamine-O-sulfonic acid; In water; at 0 - 20 ℃;

Reference yield:

C11H15O4S2(1-)*Li(1+) → 3-(2,5,5-Trimethyl-1,3-dioxane-2-yl)-thiophene-2-sulfonamide (138890-87-6)

Guidance literature:

With sodium acetate; hydroxylamine-O-sulfonic acid; In water; at 0 - 20 ℃;

Reference yield: 81.0%

3-(2,5,5-Trimethyl-1,3-dioxane-2-yl)-thiophene-2-sulfonamide (138890-87-6) → 3-Acetylthiophene-2-sulfonamide (138890-88-7)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; for 1h; Reflux;

upstream raw materials:

3-(2,5,5-Trimethyl-l,3-dioxane-2-yl)thiophene

Downstream raw materials:

3-Acetylthiophene-2-sulfonamide

Refernces

• 1、 -. "SULFONAMIDE INHIBITORS OF CARBONIC ANHYDRASE". Page/Page column 14-15. . Retrieved 2010/12/29.
• 2、 -. "Carbonic anhydrase inhibitors". . . Retrieved 2008/06/13.