4-[[(4-Chlorophenylsulfonyl)amino]methyl]benzoic acid

Base Information

Chemical Name:4-[[(4-Chlorophenylsulfonyl)amino]methyl]benzoic acid
CAS No.:138914-23-5
Molecular Formula:C14H12ClNO4S
Molecular Weight:325.76700
Hs Code.:
Mol file:138914-23-5.mol

Synonyms:4-[(4-chlorophenylsulfonamido)methyl]benzoic acid;4-[(4-Chloro-benzenesulfonylamino)-methyl]-benzoic acid;

Suppliers and Price of 4-[[(4-Chlorophenylsulfonyl)amino]methyl]benzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 2 raw suppliers

Chemical Property of 4-[[(4-Chlorophenylsulfonyl)amino]methyl]benzoic acid

Chemical Property:

Boiling Point:537.2±60.0 °C(Predicted)
PKA:4.16±0.10(Predicted)
PSA：91.85000
Density:1.446±0.06 g/cm3(Predicted)
LogP:3.98840

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

MSDS Files:

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Technology Process of 4-[[(4-Chlorophenylsulfonyl)amino]methyl]benzoic acid

There total 2 articles about 4-[[(4-Chlorophenylsulfonyl)amino]methyl]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1186212-02-1
methyl 4-(((4-chlorophenyl)sulfonamido)methyl)benzoate

: 138914-23-5
4-((((4-chlorophenyl)sulfonyl)amino)methyl)benzoic acid

Guidance literature:: With potassium hydroxide; In methanol; at 60 ℃; for 4h;
DOI:10.1016/j.bmcl.2009.05.033

Reference yield:

: 98-60-2
4-chlorobenzenesulfonyl chloride

: 138914-23-5
4-((((4-chlorophenyl)sulfonyl)amino)methyl)benzoic acid

Guidance literature:: With sodium hydroxide; potassium carbonate; Multistep reaction; 1.) 80 deg C, 90 min, 2.) MeOH, RT, 2 h;
DOI:10.1016/0223-5234(91)90009-C

Reference yield: 69.0%

: 138914-23-5
4-((((4-chlorophenyl)sulfonyl)amino)methyl)benzoic acid

: 141-91-3,6485-45-6,6485-55-8
cis-2,6-dimethylmorpholine

: 1186211-88-0
4-chloro-N-{4-[(2R,6S)-2,6-dimethylmorpholine-4-carbonyl]benzyl}benzenesulfonamide

Guidance literature:: 4-((((4-chlorophenyl)sulfonyl)amino)methyl)benzoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 1h;

cis-2,6-dimethylmorpholine; In dichloromethane; for 12h;
DOI:10.1016/j.bmcl.2009.05.033