Chemical Property of Meisoindigo
Chemical Property:
- Vapor Pressure:1.89E-09mmHg at 25°C
- Melting Point:236-237°C
- Refractive Index:1.698
- Boiling Point:482 °C at 760 mmHg
- Flash Point:245.3 °C
- PSA：49.41000
- Density:1.381 g/cm3
- LogP:2.72890
- Storage Temp.:Sealed in dry,Room Temperature
- Solubility.:insoluble in H2O; insoluble in EtOH; ≥25.85 mg/mL in DMSO with ultrasonic
- XLogP3:2.6
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:1
- Exact Mass:276.089877630
- Heavy Atom Count:21
- Complexity:614
- Purity/Quality:
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99% *data from raw suppliers
Meisoindigo *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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Useful:
- Canonical SMILES:CN1C2=CC=CC=C2C(=C1O)C3=C4C=CC=CC4=NC3=O
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Description
Meisoindigo is a derivative of indirubin that has anticancer activity. It inhibits the growth of NB4, HL-60, and U937 leukemia and primary acute myeloid leukemia (AML) cells when used at concentrations of 5 and 10 μM. It also halts the cell cycle at the G0/G1 phase and induces apoptosis in leukemia cell lines and primary AML cells, induces myeloid differentiation, and potentiates the effects of cytarabine and idarubicin . Meisoindigo (10 μM) also induces apoptosis, decreases adherence, and decreases the expression of vascular cell adhesion molecule-1 (VCAM-1) in ECV304 human vein endothelial cells. Meisoindigo (50-150 mg/kg per day) decreases spleen size in an HL-60 mouse xenograft model of AML in a dose-dependent manner.
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Uses
Meisoindigo is a 5-HT3 receptor antagonist prevents acute nausea and vomiting associated with emetogenic cancer chemotherapy Meisoindigo shows strong anti-proliferation effect against gemcitabine-resistant Pancreatic ductal adenocarcinoma (PDACs).
