N-Methylisatin

Base Information

Chemical Name:N-Methylisatin
CAS No.:2058-74-4
Molecular Formula:C9H7NO2
Molecular Weight:161.16
Hs Code.:29337900
European Community (EC) Number:218-164-9
NSC Number:42449
UNII:CNV9DH4SXQ
DSSTox Substance ID:DTXSID80174591
Nikkaji Number:J7.314H
Wikidata:Q72492141
ChEMBL ID:CHEMBL60569
Mol file:2058-74-4.mol

Synonyms:1-methyl-1H-indole-2,3-dione;1-methylisatin;N-methylisatin

Suppliers and Price of N-Methylisatin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-Methyl-1H-indole-2,3-dione
50mg
$ 60.00

TCI Chemical
1-Methylisatin >98.0%(GC)
5g
$ 261.00

TCI Chemical
1-Methylisatin >98.0%(GC)
1g
$ 73.00

SynQuest Laboratories
1-Methylisatin 98%
5 g
$ 154.00

Sigma-Aldrich
1-Methylisatin 97%
10g
$ 240.00

Sigma-Aldrich
1-Methylisatin 97%
1g
$ 48.00

Matrix Scientific
1-Methyl-1H-indole-2,3-dione
500mg
$ 59.00

Crysdot
1-Methylindoline-2,3-dione 97%
100g
$ 755.00

ChemScene
1-Methylindoline-2,3-dione 98.33%
10g
$ 82.00

ChemScene
1-Methylindoline-2,3-dione 98.33%
25g
$ 168.00

Total 45 raw suppliers

Chemical Property of N-Methylisatin

Chemical Property:

Appearance/Colour:orange to brownish crystalline powder
Vapor Pressure:0.00164mmHg at 25°C
Melting Point:130-133 °C(lit.)
Refractive Index:1.607
Boiling Point:294.3 °C at 760 mmHg
PKA:-2.41±0.20(Predicted)
Flash Point:137.4 °C
PSA：37.38000
Density:1.314 g/cm³
LogP:0.91070
Storage Temp.:Keep in dark place,Inert atmosphere,Room temperature
Water Solubility.:Insoluble in water.
XLogP3:0.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:161.047678466
Heavy Atom Count:12
Complexity:237

Purity/Quality:

98% ^*data from raw suppliers

1-Methyl-1H-indole-2,3-dione ^*data from reagent suppliers

Safty Information:

Pictogram(s): T
Hazard Codes:T
Statements: 25-37/38-41
Safety Statements: 26-39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CN1C2=CC=CC=C2C(=O)C1=O
Uses 1-Methylisatin is used as a reactant for stereoselective preparation of spirobicyclic and bis-spirotricyclic pyrazolidinones, for regioselective preparation of spirocyclic oxindole-butenolides, for synthesis of spiro-oxindoles, for preparation of unsymmetrical oxindoles, for stereoselective preparation of hydroxyloxindoles via Morita-Baylis-Hillman reaction, for preparation of pyridinecarboxylic acid [(oxo)indolylidene)hydrazide derivatives (Schiff base hydrazides) as antibacterial agents. Reactant for stereoselective preparation of spirobicyclic and bis-spirotricyclic pyrazolidinonesReactant for regioselective preparation of spirocyclic oxindole-butenolidesReactant for synthesis of spiro-oxindolesReactant for preparation of unsymmetrical oxindolesReactant for stereoselective preparation of hydroxyloxindoles via Morita-Baylis-Hillman reactionReactant for preparation of pyridinecarboxylic acid [(oxo)indolylidene)hydrazide derivatives (Schiff base hydrazides) as antibacterial agents

Technology Process of N-Methylisatin

There total 162 articles about N-Methylisatin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 3335-86-2,114581-75-8,124508-46-9
3-hydroxy-1-methyl-indolin-2-one

: 2058-74-4
1-methyl-1H-indole-2,3-dione

Guidance literature:: With 3,5,3',5'-tetra-tert-butyl-4,4'-diphenoquinone; 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,2-dimethoxyethane; at 30 ℃; for 12h; Reagent/catalyst; Inert atmosphere; Sealed tube;
DOI:10.1039/c7ob00148g

Reference yield: 95.0%

: N-methyl-2-oxo-N-phenylacetamide

: 2058-74-4
1-methyl-1H-indole-2,3-dione

Guidance literature:: With ruthenium trichloride; dimethyl sulfoxide; at 100 ℃; for 1h; Reagent/catalyst; Catalytic behavior;
DOI:10.1016/j.tet.2016.04.041