1-(6-bromopyridin-3-yl)ethanol

Base Information

• Chemical Name: 1-(6-bromopyridin-3-yl)ethanol
• CAS No.: 139042-62-9
• Molecular Formula: C7H8BrNO
• Molecular Weight: 202.04900
• Mol file: 139042-62-9.mol

Synonyms:

Chemical Property of 1-(6-bromopyridin-3-yl)ethanol

Chemical Property:

• Boiling Point: 311.8±27.0 °C(Predicted)
• PKA: 13.36±0.20(Predicted)
• PSA: 33.12000
• Density: 1.555±0.06 g/cm3(Predicted)
• LogP: 1.89740

Purity/Quality:

99%min ^*data from raw suppliers

1-(6-bromopyridin-3-yl)ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(6-bromopyridin-3-yl)ethanol

There total 4 articles about 1-(6-bromopyridin-3-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-(6-bromopyridin-3-yl)ethanone (139042-59-4) → 1-(6-bromopyridin-3-yl)ethan-1-ol (139042-62-9)

Guidance literature:

1-(6-bromopyridin-3-yl)ethanone; With sodium tetrahydroborate; In ethanol; water; at 20 ℃; for 0.5h;

With water;

Reference yield:

2,5-dibromopyridine (624-28-2) + acetaldehyde (75-07-0,9002-91-9) → 1-(6-bromopyridin-3-yl)ethan-1-ol (139042-62-9)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction; 1) diethyl ether, n-hexane, -78 deg C, 75 min, 2) -78 deg C, 2h;

Reference yield:

2,5-dibromopyridine (624-28-2) + N,N-dimethyl acetamide (127-19-5,116057-81-9) → 1-(6-bromopyridin-3-yl)ethan-1-ol (139042-62-9)

Guidance literature:

2,5-dibromopyridine; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 1h;

N,N-dimethyl acetamide; In diethyl ether; hexane; at 0 ℃; for 1h;

With sodium tetrahydroborate; water; acetic acid; more than 3 stages;

upstream raw materials:

2,5-dibromopyridine

acetaldehyde

1-(6-bromopyridin-3-yl)ethanone

N,N-dimethyl acetamide

Refernces

• 1、 -. "BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE". Paragraph 0956-0957. . Retrieved 2019/10/23.
• 2、 -. "PROCESS FOR PREPARING 5-[[4-[2-[5-(1-HYDROXYETHYL)-2-PYRIDINYL]ETHOXY]PHENYL]METHYL]-2,4-THIAZOLIDINEDIONE AND SALTS THEREOF". Paragraph 0255; 0273; 0276-0280. . Retrieved 2018/07/29.