5-Acetyl-2-bromopyridine

Base Information

Chemical Name:5-Acetyl-2-bromopyridine
CAS No.:139042-59-4
Molecular Formula:C7H6BrNO
Molecular Weight:200.035
Hs Code.:29333990
European Community (EC) Number:628-397-1
DSSTox Substance ID:DTXSID50576604
Nikkaji Number:J2.409.418I
Wikidata:Q72451305
Mol file:139042-59-4.mol

Synonyms:5-Acetyl-2-bromopyridine;139042-59-4;1-(6-bromopyridin-3-yl)ethanone;2-BROMO-5-ACETYLPYRIDINE;1-(6-BROMO-PYRIDIN-3-YL)-ETHANONE;3-Acetyl-6-bromopyridine;1-(6-bromopyridin-3-yl)ethan-1-one;Ethanone, 1-(6-bromo-3-pyridinyl)-;MFCD04974527;1-(6-bromo-3-pyridyl)ethanone;5-acetyl-2-bromo-pyridine;SCHEMBL690853;DTXSID50576604;5-Acetyl-2-bromopyridine, 97%;MUKKGHQBUKOMTD-UHFFFAOYSA-N;1-(6-bromopyridin-3-yl)-ethanone;AC-152;AKOS005258858;AB21520;CS-W019730;PS-3776;HY-60206;SY007796;AM20070122;A25568;EN300-100922;Z1269224642;5-acetyl-2-bromopyridine;1-(6-Bromopyridin-3-yl)ethan-1-one;2-Bromo-5-acetylpyridine

Suppliers and Price of 5-Acetyl-2-bromopyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Bromo-5-acetylpyridine
1g
$ 75.00

TCI Chemical
5-Acetyl-2-bromopyridine >98.0%(GC)
5g
$ 122.00

TCI Chemical
5-Acetyl-2-bromopyridine >98.0%(GC)
1g
$ 38.00

SynQuest Laboratories
5-Acetyl-2-bromopyridine
5 g
$ 87.00

SynQuest Laboratories
5-Acetyl-2-bromopyridine
1 g
$ 21.00

SynChem
2-BROMO-5-ACETYLPYRIDINE 95%
1 g
$ 30.00

Sigma-Aldrich
5-Acetyl-2-bromopyridine 97%
5g
$ 330.00

Sigma-Aldrich
5-Acetyl-2-bromopyridine 97%
1g
$ 83.70

Oakwood
1-(6-Bromopyridin-3-yl)ethanone 97%
1g
$ 10.00

Matrix Scientific
2-Bromo-5-acetylpyridine 98%
5g
$ 58.00

Total 84 raw suppliers

Chemical Property of 5-Acetyl-2-bromopyridine

Chemical Property:

Appearance/Colour:light yellow to dark yellow liquid
Vapor Pressure:0.00196mmHg at 25°C
Melting Point:124-128 °C
Refractive Index:1.558
Boiling Point:291.3 °C at 760 mmHg
PKA:-1.01±0.10(Predicted)
Flash Point:130 °C
PSA：29.96000
Density:1.534 g/cm³
LogP:2.04670
Storage Temp.:Inert atmosphere,Room Temperature
Solubility.:soluble in Methanol
XLogP3:1.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:198.96328
Heavy Atom Count:10
Complexity:138

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-5-acetylpyridine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:

Useful:

Canonical SMILES:CC(=O)C1=CN=C(C=C1)Br

Technology Process of 5-Acetyl-2-bromopyridine

There total 3 articles about 5-Acetyl-2-bromopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 624-28-2
2,5-dibromopyridine

: di-[(E)-5-(1-tert-butyldimethylsilyloxyiminoethyl)pyrid-2-yl]disulphide

: 139042-59-4
1-(6-bromopyridin-3-yl)ethanone

Guidance literature:

Reference yield: 51.0%

: 624-28-2
2,5-dibromopyridine

: 127-19-5,116057-81-9
N,N-dimethyl acetamide

: 139042-59-4
1-(6-bromopyridin-3-yl)ethanone

Guidance literature:: 2,5-dibromopyridine; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 0.5h;

N,N-dimethyl acetamide; In diethyl ether; hexane; at -78 - 20 ℃; for 1h; Further stages.;
DOI:10.3390/molecules13040818

Reference yield: 44.0%

: 13534-97-9
6-bromopyridine-3-amine

: 431-03-8
dimethylglyoxal

: 139042-59-4
1-(6-bromopyridin-3-yl)ethanone

Guidance literature:: 6-bromopyridine-3-amine; With tetrafluoroboric acid; tert.-butylnitrite; In ethanol; water; at 0 - 20 ℃; for 1h; Schlenk technique; Inert atmosphere; Green chemistry;

dimethylglyoxal; In water; at 20 ℃; Inert atmosphere; Irradiation; Green chemistry;
DOI:10.1021/acs.joc.1c01290