[1,1'-Biphenyl]-2-carboxylic acid, 4'-[[[[2-(1-oxopentyl)hydrazino]carbonyl]amino]methyl]-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: [1,1'-Biphenyl]-2-carboxylic acid, 4'-[[[[2-(1-oxopentyl)hydrazino]carbonyl]amino]methyl]-, 1,1-dimethylethyl ester
• CAS No.: 139476-13-4
• Molecular Formula: C24H31N3O4
• Mol file: 139476-13-4.mol

Synonyms:

Chemical Property of [1,1'-Biphenyl]-2-carboxylic acid, 4'-[[[[2-(1-oxopentyl)hydrazino]carbonyl]amino]methyl]-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [1,1'-Biphenyl]-2-carboxylic acid, 4'-[[[[2-(1-oxopentyl)hydrazino]carbonyl]amino]methyl]-, 1,1-dimethylethyl ester

There total 1 articles about [1,1'-Biphenyl]-2-carboxylic acid, 4'-[[[[2-(1-oxopentyl)hydrazino]carbonyl]amino]methyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ hydrazine carboxamide (4426-72-6,51433-48-8,57-56-7) + tert-butyl 4'-<<<<2-(1-oxopentyl)hydrazino>carbonyl>amino>methyl><1,1'-biphenyl>-2-carboxylate (139476-13-4)

Guidance literature:

Reference yield:

tert-butyl 4'-<<<<2-(1-oxopentyl)hydrazino>carbonyl>amino>methyl><1,1'-biphenyl>-2-carboxylate (139476-13-4) → 4'-<(1,3-dibutyl-4,5-dihydro-5-oxo-1H-1,2,4-triazol-4-yl)methyl><1,1'-biphenyl>-2-carboxylic acid

Guidance literature:

Multi-step reaction with 3 steps

1: NaOCH₃ / methanol / 30 h / Heating

2: t-BuOK / dimethylformamide; tetrahydrofuran / 17 h / 25 °C

3: 100 percent / trifluoroacetic acid / CHCl₃ / 15 h / Ambient temperature

With potassium tert-butylate; sodium methylate; trifluoroacetic acid; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide;

DOI:10.1021/jm00067a015

Reference yield:

tert-butyl 4'-<<<<2-(1-oxopentyl)hydrazino>carbonyl>amino>methyl><1,1'-biphenyl>-2-carboxylate (139476-13-4) → 4'-(1,3-Dibutyl-5-oxo-1,5-dihydro-[1,2,4]triazol-4-ylmethyl)-biphenyl-2-carboxylic acid tert-butyl ester (139476-15-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOCH₃ / methanol / 30 h / Heating

2: t-BuOK / dimethylformamide; tetrahydrofuran / 17 h / 25 °C

With potassium tert-butylate; sodium methylate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00067a015

Downstream raw materials:

4'-(1,3-Dibutyl-5-oxo-1,5-dihydro-[1,2,4]triazol-4-ylmethyl)-biphenyl-2-carboxylic acid tert-butyl ester

Refernces