139476-15-6

Basic information

• Product Name: [1,1'-Biphenyl]-2-carboxylic acid, 4'-[(1,3-dibutyl-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl)methyl]-, 1,1-dimethylethyl ester
• CAS NO: 139476-15-6
• Molecular Formula: C28H37N3O3
• Molecular Weight: 463.62
• Mol File: 139476-15-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [1,1'-Biphenyl]-2-carboxylic acid, 4'-[(1,3-dibutyl-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl)methyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [1,1'-Biphenyl]-2-carboxylic acid, 4'-[(1,3-dibutyl-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl)methyl]-, 1,1-dimethylethyl ester(139476-15-6)
• EPA Substance Registry System: [1,1'-Biphenyl]-2-carboxylic acid, 4'-[(1,3-dibutyl-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl)methyl]-, 1,1-dimethylethyl ester(139476-15-6)

Safety Data

• Hazardous Substances Data: 139476-15-6(Hazardous Substances Data)

Upstream product

• 7148-03-0 o-tolylbenzoic acid 
• 139476-12-3 4'-(Azidomethyl)[1,1'-biphenyl]-2-carboxylic acid,1,1-dimethylethyl ester 
• 139476-13-4 tert-butyl 4'-<<<<2-(1-oxopentyl)hydrazino>carbonyl>amino>methyl><1,1'-biphenyl>-2-carboxylate 
• 133690-73-0 4'-(Aminomethyl)[1,1'-biphenyl]-2-carboxylic acid,1,1-dimethylethyl ester 
• 114772-40-6 4'-bromomethyl-biphenyl-2-carboxylic acid tert-butyl ester 
• 114772-36-0 tert-butyl 4'-methyl-2-biphenylcarboxylate 
• 114772-34-8 methyl 4'-methylbiphenyl-2-carboxylate 
• 542-69-8 1-iodo-butane 
• 139476-14-5 tert-butyl 4'-<(3-butyl-4,5-dihydro-5-oxo-1,2,4-triazol-4-yl)methyl><1,1'-biphenyl>-2-carboxylate 

Relevant articles and documents

Synthesis and Structure-Activity Relationships of Nonpeptide, Potent Triazolone-Based Angiotensin II Receptor Antagonists

2,5-Dibutyl-2,4-dihydro-4--4'-yl>methyl>-3H-1,2,4-triazol-3-one, SC-51316, was synthesized as a potent and orally active angiotensin II (AII) receptor antagonist with a long duration of action.To explore the lipophilic pocket in the AII receptor interacting with the substituent at the 2-position of triazolone-based antagonists, a series of compounds were prepared and evaluated for receptor binding affinity and antagonism of AII-contracted rabbitaortic rings.It has been found that the pocket is very spacious and can accommodate different sizes of lipophilic groups and various functionalities.Acidic groups generally result in a slight decrease in binding affinity.Branched chains are unfavorable.The freedom of rotation around C2-C3 in the flexible side chain is crucial for good binding.The 2-phenylethyl-substituted triazolone analogue exhibits the highest in vitro potency among all compounds that have been synthesized.