3-Chloro-7-fluoro-2-hydroxy-3-phenylquinolin-4(3H)-one

Base Information

Chemical Name:3-Chloro-7-fluoro-2-hydroxy-3-phenylquinolin-4(3H)-one
CAS No.:144603-40-7
Molecular Formula:C15H9 Cl F N O2
Molecular Weight:289.6889
Hs Code.:2933499090
DSSTox Substance ID:DTXSID40932356
Wikidata:Q82908051
Mol file:144603-40-7.mol

Synonyms:DTXSID40932356;3-Chloro-7-fluoro-2-hydroxy-3-phenylquinolin-4(3H)-one

Suppliers and Price of 3-Chloro-7-fluoro-2-hydroxy-3-phenylquinolin-4(3H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 3-Chloro-7-fluoro-2-hydroxy-3-phenylquinolin-4(3H)-one

Chemical Property:

Vapor Pressure:2.44E-09mmHg at 25°C
Boiling Point:479°Cat760mmHg
Flash Point:243.5°C
PSA：46.17000
Density:1.45g/cm³
LogP:3.23280
XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:289.0305844
Heavy Atom Count:20
Complexity:424

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2(C(=O)C3=C(C=C(C=C3)F)NC2=O)Cl
Isomeric SMILES:C1=CC=C(C=C1)[C@]2(C(=O)C3=C(C=C(C=C3)F)NC2=O)Cl

Technology Process of 3-Chloro-7-fluoro-2-hydroxy-3-phenylquinolin-4(3H)-one

There total 3 articles about 3-Chloro-7-fluoro-2-hydroxy-3-phenylquinolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 144603-09-8
7-Fluoro-4-hydroxy-3-phenyl-1H-quinolin-2-one

: 144603-40-7
3-Chloro-7-fluoro-3-phenyl-1H-quinoline-2,4-dione

Guidance literature:: With sulfuryl dichloride; In 1,4-dioxane; at 40 - 60 ℃; for 0.166667h;
DOI:10.1007/BF00816857

Reference yield:

: 372-19-0
meta-fluoroaniline

: 144603-40-7
3-Chloro-7-fluoro-3-phenyl-1H-quinoline-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / 2 h / 300 °C

2: 54 percent / SO₂Cl₂ / dioxane / 0.17 h / 40 - 60 °C

With sulfuryl dichloride; In 1,4-dioxane;
DOI:10.1007/BF00816857

Reference yield:

: 83-13-6
diethyl 2-phenylmalonate

: 144603-40-7
3-Chloro-7-fluoro-3-phenyl-1H-quinoline-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / 2 h / 300 °C

2: 54 percent / SO₂Cl₂ / dioxane / 0.17 h / 40 - 60 °C

With sulfuryl dichloride; In 1,4-dioxane;
DOI:10.1007/BF00816857