9-Phenyl-9,10-dihydroacridine

Base Information

• Chemical Name: 9-Phenyl-9,10-dihydroacridine
• CAS No.: 10537-12-9
• Molecular Formula: C19H15 N
• Molecular Weight: 257.335
• Hs Code.: 2933990090
• Mol file: 10537-12-9.mol

Synonyms:Acridan,9-phenyl- (6CI,7CI,8CI); 9-Phenyl-9,10-dihydroacridine; 9-Phenylacridan; NSC274898

Chemical Property of 9-Phenyl-9,10-dihydroacridine

Chemical Property:

• Vapor Pressure: 2.79E-06mmHg at 25°C
• Melting Point: 170 °C
• Boiling Point: 389.8°Cat760mmHg
• PKA: 1.57±0.40(Predicted)
• Flash Point: 200.7°C
• PSA: 12.03000
• Density: 1.137g/cm³
• LogP: 5.06180

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 9-Phenyl-9,10-dihydroacridine

There total 18 articles about 9-Phenyl-9,10-dihydroacridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

acridine (260-94-6) + phenyllithium (591-51-5) → 9-phenyl-9,10-dihydroacridine (10537-12-9)

Guidance literature:

acridine; phenyllithium; With N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; diethyl ether; at 0 ℃; for 2h;

With water; Further stages.;

DOI:10.1016/j.tetlet.2003.09.167

Reference yield: 70.0%

9-phenylacridine (602-56-2) → 9-phenyl-9,10-dihydroacridine (10537-12-9)

Guidance literature:

With hydrogen; In toluene; at 120 ℃; for 48h; under 22502.3 Torr; Autoclave;

DOI:10.1021/jacs.5b06496

Reference yield: 58.0%

9-phenylacridine (602-56-2) → 9-phenyl-1,2,3,4-tetrahydroacridine (10265-83-5) + 9-phenyl-1,2,3,4,5,6,7,8-octahydro-acridine (22575-89-9) + 9-phenyl-9,10-dihydroacridine (10537-12-9)

Guidance literature:

With hydrogenchloride; nickel-aluminium; In 1,4-dioxane; at 95 ℃;

DOI:10.3987/com-98-8198

upstream raw materials:

acridine

phenyllithium

9-phenylacridine

9-(2-iodo-phenyl)-9,10-dihydro-acridine

Downstream raw materials:

10-benzyl-9-phenyl-(9,10-dihydroacridine)

10-methyl-9-phenyl-9,10-dihydroacridine

9-phenylacridine

9-phenyl-4-(2-tolyl)acridine

Refernces

• 1、 Hernán-Gómez, Alberto,Herd, Emma,Uzelac, Marina,Cadenbach, Thomas,Kennedy, Alan R.,Borilovic, Ivana,Aromí, Guillem,Hevia, Eva. "Zincate-Mediated Arylation Reactions of Acridine: Pre- and Postarylation Structural Insights". . p. 2614 - 2623. Retrieved 2015.
• 2、 Dutta, Bishnupada,Kar, Gandhi K.,Ray, Jayanta K.. "Direct regioselective phenylation of acridine derivatives by phenyllithium". . p. 8641 - 8643. Retrieved 2008/04/18.