9-Phenyl-1,2,3,4-tetrahydroacridine

Base Information

• Chemical Name: 9-Phenyl-1,2,3,4-tetrahydroacridine
• CAS No.: 10265-83-5
• Molecular Formula: C19H17N
• Molecular Weight: 259.351
• DSSTox Substance ID: DTXSID70452254
• Nikkaji Number: J992.692E
• Wikidata: Q82272760
• ChEMBL ID: CHEMBL3975401
• Mol file: 10265-83-5.mol

Synonyms:9-phenyl-1,2,3,4-tetrahydroacridine;10265-83-5;Acridine, 1,2,3,4-tetrahydro-9-phenyl-;CHEMBL3975401;DTXSID70452254;MFCD03413718;1,2,3,4-Tetrahydro-9-phenylacridine;9-Phenyl-1,2,3,4-tetrahydro-acridine

Chemical Property of 9-Phenyl-1,2,3,4-tetrahydroacridine

Chemical Property:

• XLogP3: 5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 259.136099547
• Heavy Atom Count: 20
• Complexity: 320

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC2=NC3=CC=CC=C3C(=C2C1)C4=CC=CC=C4

Technology Process of 9-Phenyl-1,2,3,4-tetrahydroacridine

There total 18 articles about 9-Phenyl-1,2,3,4-tetrahydroacridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + (2-aminophenyl)(phenyl)methanone (2835-77-0) → 9-phenyl-1,2,3,4-tetrahydroacridine (10265-83-5)

Guidance literature:

With o-benzenedisulfonimide; at 80 ℃; for 6h; Neat (no solvent);

DOI:10.1016/j.tetlet.2010.02.139

Reference yield: 92.0%

(2-aminophenyl)(phenyl)methanol (13209-38-6) + cyclohexanol (108-93-0) → 9-phenyl-1,2,3,4-tetrahydroacridine (10265-83-5)

Guidance literature:

With benzophenone; dichlorotetrakis(dimethyl sulfoxide)ruthenium(II); potassium tert-butylate; at 100 ℃; for 48h;

DOI:10.1002/ejoc.200600945

Reference yield: 91.0%

(2-aminophenyl)(phenyl)methanone (2835-77-0) + cyclohexanol (108-93-0) → 9-phenyl-1,2,3,4-tetrahydroacridine (10265-83-5)

Guidance literature:

With potassium hydroxide; at 80 ℃; for 7h;

DOI:10.1039/c5ob01422k

upstream raw materials:

9-phenylacridine

cyclohexanone

(2-aminophenyl)(phenyl)methanone

cyclohexanol

Downstream raw materials:

9-phenylacridine