Phenol, 2-iodo-3-(phenylmethoxy)-

Base Information

Chemical Name:Phenol, 2-iodo-3-(phenylmethoxy)-
CAS No.:140201-75-8
Molecular Formula:C13H11IO2
Molecular Weight:326.134
Hs Code.:
DSSTox Substance ID:DTXSID60471196
Nikkaji Number:J1.143.362F

Synonyms:Phenol, 2-iodo-3-(phenylmethoxy)-;140201-75-8;DTXSID60471196

Suppliers and Price of Phenol, 2-iodo-3-(phenylmethoxy)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of Phenol, 2-iodo-3-(phenylmethoxy)-

Chemical Property:

XLogP3:3.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:325.98038
Heavy Atom Count:16
Complexity:204

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)COC2=CC=CC(=C2I)O

Technology Process of Phenol, 2-iodo-3-(phenylmethoxy)-

There total 14 articles about Phenol, 2-iodo-3-(phenylmethoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 41046-67-7
2-iodoresorcinol

: 100-39-0
benzyl bromide

: 140201-75-8
3-(benzyloxy)-2-iodophenol

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1016/0040-4020(95)00456-I

Reference yield:

: 6-(3-Benzyloxy-2-iodo-phenoxy)-3,4-dihydro-2H-pyran

: 140201-75-8
3-(benzyloxy)-2-iodophenol

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol;
DOI:10.1021/ja00035a069

Reference yield:

: 136-36-7
benzoate d'hydroxy-3 phenyle

: 140201-75-8
3-(benzyloxy)-2-iodophenol

Guidance literature:: Multi-step reaction with 7 steps

1: 99.9 percent / i-Pr₂NEt / CH₂Cl₂ / 18 h / Heating

2: 100 percent / 3 N aq. NaOH / methanol / 2 h / Ambient temperature

3: 95.4 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 60 h / Ambient temperature

4: 1.) n-BuLi, 2.) I₂ / 1.) hexane, 0 deg C, 3.5 h, 2.) hexane, Et₂O, 0 deg C, 30 min

5: pyridinium p-toluenesulfonate / ethanol / 1.5 h / 70 °C

6: 1.) NaH, 2.) n-Bu₄NI / 1.) THF, RT, 30 min, 2.) THF, RT, 1.5 h

7: 97.1 percent / 4 N aq. HCl / methanol; dioxane / 5 h / 50 °C

With hydrogenchloride; sodium hydroxide; n-butyllithium; iodine; pyridinium p-toluenesulfonate; tetra-(n-butyl)ammonium iodide; sodium hydride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; ethanol; dichloromethane;
DOI:10.1021/ja00082a023