6H-Purin-6-one, 1,7-dihydro-2-[[1-(hydroxymethyl)cyclopentyl]amino]-1-methyl-7-(phenyl methyl)-

Base Information

• Chemical Name: 6H-Purin-6-one, 1,7-dihydro-2-[[1-(hydroxymethyl)cyclopentyl]amino]-1-methyl-7-(phenyl methyl)-
• CAS No.: 140396-16-3
• Molecular Formula: C19H23N5O2
• Molecular Weight: 353.424
• Mol file: 140396-16-3.mol

Synonyms:

Chemical Property of 6H-Purin-6-one, 1,7-dihydro-2-[[1-(hydroxymethyl)cyclopentyl]amino]-1-methyl-7-(phenyl methyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6H-Purin-6-one, 1,7-dihydro-2-[[1-(hydroxymethyl)cyclopentyl]amino]-1-methyl-7-(phenyl methyl)-

There total 3 articles about 6H-Purin-6-one, 1,7-dihydro-2-[[1-(hydroxymethyl)cyclopentyl]amino]-1-methyl-7-(phenyl methyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1-aminocyclopentyl)methanol (10316-79-7) + 7-benzyl-2-chloro-1-methyl-1,7-dihydro-6H-purin-6-one (140379-24-4) → 7-Benzyl-2-(1-hydroxymethyl-cyclopentylamino)-1-methyl-1,7-dihydro-purin-6-one (140396-16-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In various solvent(s); at 130 ℃;

DOI:10.1021/jm9608467

Reference yield:

7-benzyl-1-methyl-3,7-dihydro-purine-2,6-dione (70404-25-0) → 7-Benzyl-2-(1-hydroxymethyl-cyclopentylamino)-1-methyl-1,7-dihydro-purin-6-one (140396-16-3)

Guidance literature:

Multi-step reaction with 2 steps

1: POCl₃ / 7 h / Heating

2: diisopropylethylamine / various solvent(s) / 130 °C

With N-ethyl-N,N-diisopropylamine; trichlorophosphate; In various solvent(s);

DOI:10.1021/jm9608467

Reference yield:

6-amino-5-(benzylamino)-3-methylpyrimidine-2,4(1H,3H)-dione (2034-31-3) → 7-Benzyl-2-(1-hydroxymethyl-cyclopentylamino)-1-methyl-1,7-dihydro-purin-6-one (140396-16-3)

Guidance literature:

Multi-step reaction with 3 steps

1: dimethylformamide / 5 h / 110 °C

2: POCl₃ / 7 h / Heating

3: diisopropylethylamine / various solvent(s) / 130 °C

With N-ethyl-N,N-diisopropylamine; trichlorophosphate; In N,N-dimethyl-formamide;

DOI:10.1021/jm9608467

upstream raw materials:

(1-aminocyclopentyl)methanol

7-benzyl-2-chloro-1-methyl-1,7-dihydro-6H-purin-6-one

7-benzyl-1-methyl-3,7-dihydro-purine-2,6-dione

6-amino-5-(benzylamino)-3-methylpyrimidine-2,4(1H,3H)-dione

Downstream raw materials:

5'-methyl-3'-(phenylmethyl)spiro[cyclopentane-1,7'(8'H)-[3H]imidazo[2,1-b]purin]-4(5'H)-one