10316-79-7

Basic information

• Product Name: CYCLOLEUCINOL
• Synonyms: CyclopentaneMethanol, 1-aMino-;(1-aMinocyclopentyl) Methanol hydrochloride;1-AMino-1-cyclopentaneMethanol 97%;1-Hydroxymethylcyclopentanamine;(1-Aminocyclopentyl);CYCLOLEUCINOL;1-AMINO-1-HYDROXYMETHYLCYCLOPENTANE;1-AMINO-1-CYCLOPENTANEMETHANOL
• CAS NO: 10316-79-7
• Molecular Formula: C₆H₁₃NO
• Molecular Weight: 115.17
• EINECS: 233-697-7
• Product Categories: Chemical Synthesis;Organic Building Blocks;Oxygen Compounds;pharmacetical;Amino Alcohols;Building Blocks
• Mol File: 10316-79-7.mol
• Article Data: 10

Chemical Properties

• Melting Point: 20 °C(lit.)
• Boiling Point: 85-90 °C10 mm Hg(lit.)
• Flash Point: 204 °F
• Appearance: /
• Density: 0.9837 (rough estimate)
• Vapor Pressure: 0.152mmHg at 25°C
• Refractive Index: 1.4713 (estimate)
• PKA: 15.05±0.10(Predicted)
• CAS DataBase Reference: CYCLOLEUCINOL(CAS DataBase Reference)
• NIST Chemistry Reference: CYCLOLEUCINOL(10316-79-7)
• EPA Substance Registry System: CYCLOLEUCINOL(10316-79-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: GY4620000
• Hazardous Substances Data: 10316-79-7(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 10316-79-7 differently. You can refer to the following data:
1. CYCLOLEUCINOL Often used building block in medicinal chemistry synthesis.1,2
2. 1-Amino-1-cyclopentanemethanol was used in the synthesis of xanthine-derived heterocyclic fused systems. It was also used as building block in medicinal chemistry synthesis.

InChI:InChI=1/C6H13NO/c7-6(5-8)3-1-2-4-6/h8H,1-5,7H2/p+1

Upstream product

• 1664-35-3 ethyl 1-aminocyclopentanecarboxylate 
• 52-52-8 1-amino-1-cyclopentanecarboxylic acid 
• 60421-23-0 cycloleucine methyl ester hydrochloride 
• 78388-61-1 cycloleucine methyl ester 
• 49830-37-7 1-amino-1-cyanocyclopentane 
• 120-92-3 cyclopentanone 
• 54378-87-9 1,1-cyclopentanedicarboxylic acid monoethyl ester 
• 4167-77-5 cyclopentane-1,1-dicarboxylic acid diethyl ester 
• 185-60-4 1-oxaspiro[2.4]heptane 
• 404344-97-4 1-azido-1-hydroxymethylcyclopentane 
• 76910-12-8 1-Chlorformyl-1-cyclopentancarbonsaeure-ethylester 

Downstream Products

• 917893-90-4 (4S,5R)-5-[2-(Diphenyl-phosphinoyl)-phenyl]-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid (1-hydroxymethyl-cyclopentyl)-amide 
• 676560-72-8 N-benzyloxycarbonyl-1-(hydroxymethyl)-1-cyclopentylamine 
• 247567-04-0 2-[1-(Hydroxymethyl)cyclopentylamino]-5-nitro-N-(1,3-benzodioxol-5-ylmethyl)benzamide 
• 10316-99-1 (1-ammoniocyclopentyl)methyl sulfate 
• 294648-13-8 C₂₁H₂₇BrN₆O 
• 1226884-89-4 1-(4-(1-(hydroxymethyl)cyclopentylamino)-2-(4-(oxazol-5-yl)phenylamino)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)ethanone 
• 1027185-05-2 7-Benzyl-8-cyclopentylmethyl-2-(1-hydroxymethyl-cyclopentylamino)-1-methyl-1,7-dihydro-purin-6-one 
• 1027187-33-2 7-Benzyl-2-(1-hydroxymethyl-cyclopentylamino)-1-methyl-8-phenyl-1,7-dihydro-purin-6-one 
• 140396-16-3 7-Benzyl-2-(1-hydroxymethyl-cyclopentylamino)-1-methyl-1,7-dihydro-purin-6-one 
• 76910-14-0 1<(6-Chlor-5-nitro-4-pyrimidinyl)amino>-1-cyclopentanmethanol 
• 76910-15-1 1,1'-<(5-Nitro-4,6-pyrimidindiyl)diamino>-1,1'-dicyclopentanmethanol 

Relevant articles and documents

Design and Synthesis of Fsp3-Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening

The exploration of innovative chemical space is a critical step in the early phases of drug discovery. Bis-spirocyclic frameworks occur in natural products and other biologically relevant metabolites and show attractive features, such as molecular compactness, structural complexity, and three-dimensional character. A concise approach to the synthesis of bis-spirocyclic-based compound libraries starting from readily available commercial reagents and robust chemical transformations has been developed. A number of novel bis-spirocyclic scaffold examples, as implemented in the European Lead Factory project, is presented.

TRICYCLIC LACTAMS FOR USE IN THE PROTECTION OF NORMAL CELLS DURING CHEMOTHERAPY

This invention is in the area of tricyclic lactam compounds, compositions and methods of protecting healthy cells, and in particular hematopoietic stem and progenitor cells (HSPC) as well as renal cells, from damage associated with DNA damaging chemotherapeutic agents. In one aspect, protection of healthy cells is disclosed using compounds that act as cyclin-dependent kinase 4/6 (CDK 4/6) inhibitors when administered to subjects undergoing DNA damaging chemotherapeutic regimens for the treatment of proliferative disorders.

AMINOALCOHOL AND BIOCIDE COMPOSITIONS FOR AQUEOUS BASED SYSTEMS

Biocidal compositions and their use in aqueous media, such as metalworking fluids, the compositions comprising a biocidal agent; and a non-biocidal primary amino alcohol compound of the formula (I): wherein R1, R2, R3, R4, and R5 are as defined herein.