Chemical Property of 2-Chloro-2-hydroxyiminoacetic acid ethyl ester
Chemical Property:
- Appearance/Colour:Brown crystal
- Vapor Pressure:0.0124mmHg at 25°C
- Melting Point:70-76 °C(lit.)
- Refractive Index:1.48
- Boiling Point:230.5 °C at 760 mmHg
- PKA:7.60±0.10(Predicted)
- Flash Point:93.2 °C
- PSA:58.89000
- Density:1.36 g/cm3
- LogP:0.57600
- Storage Temp.:2-8°C
- Sensitive.:Moisture Sensitive/Lachrymatory
- Solubility.:soluble in Methanol
- XLogP3:2.2
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:3
- Exact Mass:151.0036207
- Heavy Atom Count:9
- Complexity:134
- Purity/Quality:
-
99% *data from raw suppliers
Ethyl 2-Chloro-2-(hydroxyimino)acetate *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn,
Xi
- Hazard Codes:Xn,Xi
- Statements:
37/38-41-42/43-36/37/38
- Safety Statements:
22-26-36/37/39-45-36
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CCOC(=O)C(=NO)Cl
- Isomeric SMILES:CCOC(=O)/C(=N/O)/Cl
-
Uses
Ethyl 2-chloro-2-(hydroxyimino)acetate has been used:in the preparation of (+)-and (?)-Δ2-isoxazolinesin the synthesis of CIP-AS (?), a chiral amino acid structurally related to glutamic acid, potential agonist at the ionotropic (±±)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA)-kainate receptorsto generate ethoxycarbonylformonitrile oxide, in situ by treatment with sodium bicarbonateto prepare N-azirdinyloximes which on treatment with scandium triflate (418218) provide dihydro-oxadiazines