2,6-Diaminopurine arabinoside

Base Information

• Chemical Name: 2,6-Diaminopurine arabinoside
• CAS No.: 34079-68-0
• Molecular Formula: C10H14N6O4
• Molecular Weight: 282.259
• Mol file: 34079-68-0.mol

Synonyms:9H-Purine,2,6-diamino-9-β-D-arabinofuranosyl-(8CI);2,6-Diamino-9-β-D-arabinofuranosylpurine;9-β-D-Arabinofuranosyl-2,6-diaminopurine;

Chemical Property of 2,6-Diaminopurine arabinoside

Chemical Property:

• Vapor Pressure: 6.73E-27mmHg at 25°C
• Melting Point: 286-290°C
• Refractive Index: 1.985
• Boiling Point: 798.5 °C at 760 mmHg
• PKA: 13.10±0.70(Predicted)
• Flash Point: 436.7 °C
• PSA: 165.56000
• Density: 2.25 g/cm³
• LogP: -1.23540
• Storage Temp.: 2-8°C
• Solubility.: Aqueous Acid (Slightly, Sonicated), DMSO (Slightly, Heated, Sonicated), Water (S

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,6-DiaminopurineArabinoside ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,6-Diaminopurine arabinoside is used in preparation methods and devices for canine herpesvirus 1 (CHV-1) detection and prevention.

Technology Process of 2,6-Diaminopurine arabinoside

There total 3 articles about 2,6-Diaminopurine arabinoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

araU (3083-77-0) + 2,6-diaminopurine (1904-98-9) → uracil (66-22-8,144104-68-7,18324-22-6,27072-01-1,2920-92-5,51953-19-6) + 2,6-diamino-9-(β-D-arabinofuranosyl)-purine (34079-68-0)

Guidance literature:

With Enterobacter gergoviae; at 60 ℃; for 48h; pH=7; aq. phosphate buffer; Microbiological reaction;

DOI:10.1016/j.bmcl.2009.05.106

Reference yield:

9-β-D-arabinofuranosylguanine (38819-10-2) + 2,6-diaminopurine (1904-98-9) → 2,6-diamino-9-(β-D-arabinofuranosyl)-purine (34079-68-0)

Guidance literature:

With purine nucleoside 2’-deoxyribosyltransferase from Trypanosoma brucei; In aq. phosphate buffer; at 50 ℃; for 4h; pH=6; Enzymatic reaction;

DOI:10.1002/cctc.201800775

Reference yield:

9-β-D-arabinofuranosylguanine (38819-10-2) → 2,6-diamino-9-(β-D-arabinofuranosyl)-purine (34079-68-0)

Guidance literature:

Multi-step reaction with 2 steps

1: purine nucleoside 2’-deoxyribosyltransferase from Trypanosoma brucei / aq. phosphate buffer / 4 h / 50 °C / pH 6 / Enzymatic reaction

2: purine nucleoside 2’-deoxyribosyltransferase from Trypanosoma brucei / aq. phosphate buffer / 4 h / 50 °C / pH 6 / Enzymatic reaction

With purine nucleoside 2’-deoxyribosyltransferase from Trypanosoma brucei; In aq. phosphate buffer;

DOI:10.1002/cctc.201800775

upstream raw materials:

araU

2,6-diaminopurine

9-β-D-arabinofuranosylguanine

2,6-diaminopurine

Downstream raw materials:

2-fluoroadenosine

9-β-D-arabinofuranosylguanine

2'-deoxy-2'-fluoroguanosine

2’-fluoro-N2-isobutyryl-2’-deoxyguanosine

Refernces

• 1、 Medici, Rosario,Iribarren, Adolfo M.,Lewkowicz, Elizabeth S.. "Synthesis of 9-β-d-arabinofuranosylguanine by combined use of two whole cell biocatalysts". scheme or table. p. 4210 - 4212. Retrieved 2010/04/05.