Chemical Property of 2-Fluoroadenosine
Chemical Property:
- Appearance/Colour:white powder
- Melting Point:240 °C
- Refractive Index:-72 ° (C=0.1, EtOH)
- Boiling Point:747.303 °C at 760 mmHg
- PKA:13.05±0.70(Predicted)
- Flash Point:405.755 °C
- PSA：139.54000
- Density:2.176 g/cm3
- LogP:-1.25970
- Storage Temp.:Keep in dark place,Sealed in dry,Room Temperature
- Solubility.:DMSO (Slightly, Sonicated), Methanol (Slightly, Heated, Sonicated)
- XLogP3:-0.6
- Hydrogen Bond Donor Count:4
- Hydrogen Bond Acceptor Count:9
- Rotatable Bond Count:2
- Exact Mass:285.08733204
- Heavy Atom Count:20
- Complexity:367
- Purity/Quality:
-
99% *data from raw suppliers
2-Fluoroadenosine *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn
- Hazard Codes:Xn
- Statements:
22-36/37/38
- Safety Statements:
26
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1=NC2=C(N=C(N=C2N1C3C(C(C(O3)CO)O)O)F)N
- Isomeric SMILES:C1=NC2=C(N=C(N=C2N1[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)F)N
-
Description
2-Fluoroadenosine (F-Ado) was developed at Southern Research Institute in 1957 as a potential anticancer drug. 2-Fluoroadenosine is not deaminated by adenosine deaminase but metabolized to triphosphate as shown in vitro. The drug was also shown to be a potent inhibitor of lymphocyte-mediated cytolysis.
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Uses
2-Fluoroadenosine is a fluorinated analog of Adenoside nucleotide. It is used as an intermediate for the drug fludarabine. Fludarabine is a purine analogue and antineoplastic agent. It is a chemotherapy medication used in the treatment of leukemia and lymphoma.
