4-(Chloromethyl)-5-methyl-1,3-thiazole hydrochloride

Base Information

• Chemical Name: 4-(Chloromethyl)-5-methyl-1,3-thiazole hydrochloride
• CAS No.: 141305-55-7
• Molecular Formula: C5H6ClNS.ClH
• Molecular Weight: 184.08700
• Hs Code.: 2934100090
• Mol file: 141305-55-7.mol

Synonyms:

Chemical Property of 4-(Chloromethyl)-5-methyl-1,3-thiazole hydrochloride

Chemical Property:

• PSA: 41.13000
• LogP: 2.99230
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

4-(chloromethyl)-5-methyl-1,3-thiazolehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(Chloromethyl)-5-methyl-1,3-thiazole hydrochloride

There total 2 articles about 4-(Chloromethyl)-5-methyl-1,3-thiazole hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

4,5-dimethyl-1,3-thiazole 3-oxide (141305-45-5) → 4-methyl-5-thiazolylmethyl chloride (10014-52-5) + 2-chloro-4,5-dimethyl-1,3-thiazole (56355-41-0) + 4-chloromethyl-5-methylthiazole hydrochloride (141305-55-7) + 4-chloromethyl-5-methylthiazole (141305-54-6)

Guidance literature:

With acetyl chloride; for 6h;

Reference yield:

4,5-Dimethylthiazole (3581-91-7) → 4-chloromethyl-5-methylthiazole hydrochloride (141305-55-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 37 percent / m-chloroperbenzoic acid 90percent / ethyl acetate / 16 h / 20 °C

2: 10 percent / acetyl chloride / 6 h

With acetyl chloride; 3-chloro-benzenecarboperoxoic acid; In ethyl acetate;

upstream raw materials:

4,5-dimethyl-1,3-thiazole 3-oxide

4,5-Dimethylthiazole

Refernces