Isoindolo[1,2-a]isoquinoline-9,12-dione, 8-phenyl-

Base Information

• Chemical Name: Isoindolo[1,2-a]isoquinoline-9,12-dione, 8-phenyl-
• CAS No.: 141341-96-0
• Molecular Formula: C₂₂H₁₃NO₂
• Molecular Weight: 323.351
• Mol file: 141341-96-0.mol

Synonyms:

Chemical Property of Isoindolo[1,2-a]isoquinoline-9,12-dione, 8-phenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Isoindolo[1,2-a]isoquinoline-9,12-dione, 8-phenyl-

There total 7 articles about Isoindolo[1,2-a]isoquinoline-9,12-dione, 8-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

2-benzoyl-1,2-dihydroisoquinaldonitrile hydrofluoroborate + p-benzoquinone (106-51-4) → 8-phenylisoindolo[1,2-a]isoquinoline-9,12-dione (141341-96-0)

Guidance literature:

In N,N-dimethyl-formamide; at 0 ℃; for 3h;

DOI:10.1016/S0040-4039(00)91686-1

Reference yield:

N-(2-ethenylphenylmethyl)prop-2-enylamine (774181-39-4) → 8-phenylisoindolo[1,2-a]isoquinoline-9,12-dione (141341-96-0)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 1 h / 80 °C

2: (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II) / toluene / 0.08 h / Glovebox; Reflux

3: Hoveyda-Grubbs catalyst second generation / toluene / 1 h / Glovebox; Reflux

4: toluene / 0.5 h / 80 °C / Glovebox

With (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); Hoveyda-Grubbs catalyst second generation; potassium carbonate; In toluene; acetonitrile;

DOI:10.1002/adsc.201500680

Reference yield:

2-vinylbenzaldehyde (28272-96-0) → 8-phenylisoindolo[1,2-a]isoquinoline-9,12-dione (141341-96-0)

Guidance literature:

Multi-step reaction with 6 steps

1: magnesium sulfate / dichloromethane / 20 °C

2: sodium tetrahydroborate / methanol / 1.5 h / 0 °C

3: potassium carbonate / acetonitrile / 1 h / 80 °C

4: (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II) / toluene / 0.08 h / Glovebox; Reflux

5: Hoveyda-Grubbs catalyst second generation / toluene / 1 h / Glovebox; Reflux

6: toluene / 0.5 h / 80 °C / Glovebox

With sodium tetrahydroborate; (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); Hoveyda-Grubbs catalyst second generation; magnesium sulfate; potassium carbonate; In methanol; dichloromethane; toluene; acetonitrile;

DOI:10.1002/adsc.201500680

upstream raw materials:

p-benzoquinone

N-(2-ethenylphenylmethyl)prop-2-enylamine

2-vinylbenzaldehyde

N-benzyl-1,2-dihydroisoquinoline