28272-96-0

Basic information

• Product Name: 2-ethenylbenzaldehyde
• Synonyms: 2-Ethenylbenzaldehyde; Benzaldehyde, 2-ethenyl-; ETHENYLBENZALDEHYDE
• CAS NO: 28272-96-0
• Molecular Formula: C₉H₈O
• Molecular Weight: 132.1592
• Mol File: 28272-96-0.mol
• Article Data: 54

Chemical Properties

• Boiling Point: 232.5°C at 760 mmHg
• Flash Point: 111.4°C
• Density: 1.04g/cm³
• Vapor Pressure: 0.0589mmHg at 25°C
• Refractive Index: 1.607
• CAS DataBase Reference: 2-ethenylbenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ethenylbenzaldehyde(28272-96-0)
• EPA Substance Registry System: 2-ethenylbenzaldehyde(28272-96-0)

Safety Data

• Hazardous Substances Data: 28272-96-0(Hazardous Substances Data)

Upstream product

• 2591-86-8 N-Formylpiperidine 
• 2039-88-5 2-bromostyrene 
• 68-12-2 N,N-dimethyl-formamide 
• 3230-65-7 3,4-dihydroisoquinoline 
• 69460-11-3 (1R,2R,3R,5S)-(-)-Isopinocampheylamine 
• 22901-09-3 2-(2-bromoethyl)benzaldehyde 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 68913-17-7 8-Methylbicyclo[4.2.0]octa-1⁽⁶⁾,2,4-trien-7-one 
• 1826-67-1 vinyl magnesium bromide 
• 6630-33-7 ortho-bromobenzaldehyde 
• 74-85-1 ethene 
• 4363-34-2 vinylboronic acid 
• 5159-41-1 2-iodobenzyl alcohol 
• 95-13-6 1-indene 

Downstream Products

• 22927-13-5 2-ethylbenzaldehyde 
• 35106-82-2 2-vinylbenzylalcohol 
• 38846-62-7 o-<1,2-Dibromethyl>-benzaldehyd 
• 142819-86-1 C₁₄H₁₈⁽²⁾HNO 
• 122911-57-3 2-(2-styryl)indane-1,3-dione 
• 78926-45-1 o-(trans-2,3-diphenylaziridin-1-yliminomethyl)styrene 
• 80663-40-7 4'-methyl-2-vinylstilbene 
• 75135-83-0 (E,E)-6-trimethylsilyl-1-(2-vinyl-1-phenyl)-3,5-hexadien-1-ol 
• 75135-86-3 (E)-4-trimethylsilyl-2-vinyl-1-(2-vinyl-1-phenyl)-3-buten-1-ol 
• 86486-99-9 (E)-4-(2-Trimethylsilanyl-ethyl)-1-(2-vinyl-phenyl)-hexa-3,5-dien-1-ol 
• 155129-45-6 4,9-Dimethoxy-2-(2-vinyl-phenyl)-cyclopenta[b]naphthalene-1,3-dione 
• 121607-67-8 2-ethenylbenzaldoxime 
• 83-33-0 inden-1-one 
• 96689-65-5 dimethyl 2,6-dimethyl-4-(2-ethenylphenyl)-1,4-dihydro-pyridine-3,5-dicarboxylate 

Relevant articles and documents

Construction of 4-Isochromanones through Cu(OTf)2-Catalysed Sequential C=O and C–O Bond Formation

A new strategy for the facile and efficient synthesis of 4-isochromanones has been developed. The reaction involves a Cu(OTf)2-catalysed sequential reaction of epoxides carrying electron-deficient alkenes using the solvent DMSO as the oxidant.

Palladium-Catalyzed Tandem Hydrocarbonylative Lactamization and Cycloaddition Reaction for the Construction of Bridged Polycyclic Lactams

The intramolecular hydroaminocarbonylation of alkenes is a compelling tool to rapidly access lactam, a privileged motif ubiquitous in natural products, pharmaceuticals, and agrochemicals. However, selective carbonylation to bridged polycyclic lactams with a lactam nitrogen at a bridgehead position is less explored. We herein report a modular palladium-catalyzed approach to perform a tandem hydrocarbonylative lactamization/Diels-Alder cycloaddition reaction with 2-vinyl aryl aldimines, alkenes, and CO, which offers convenient access to furnish the bridged polycyclic lactams in high yields with high selectivities.

A Transient Directing Group Strategy Enables Enantioselective Multicomponent Organofluorine Synthesis

The vicinal fluorofunctionalization of alkenes represents an expedient strategy for converting feedstock olefins into valuable fluorinated molecules and as such has garnered significant attention from the synthetic community; however, current methods remain limited in terms of scope and selectivity. Here we report the site-selective palladium-catalyzed three-component coupling of alkenylbenzaldehydes, arylboronic acids, and N-fluoro-2,4,6-trimethylpyridinium hexafluorophosphate facilitated by a transient directing group. The synthetically enabling methodology constructs vicinal stereocenters with excellent regio-, diastereo-, and enantioselectivities, forging products that map onto bioactive compounds.