Synonyms:benzo-21-crown-7;67950-78-1;SCHEMBL7636964;B21C7-BENZO CROWN ETHER;DTXSID20878369;AKOS002313230;2,3,5,6,8,9,11,12,14,15,17,18-Dodecahydrobenzo[b][1,4,7,10,13,16,19]heptaoxacyclohenicosine
The study investigates a low-molecular-weight gelator (LMWG) system, specifically a compound referred to as MF, which exhibits lower critical solution temperature (LCST)-type thermo-responsiveness and an LCST-induced supramolecular gelation process. MF is an amphiphilic molecule with hydrophilic benzo-21-crown-7 (B21C7) units that facilitate LCST behavior and a hydrophobic tetrafluorobenzene core with amide linkers that control the aggregation of gelators to form supramolecular gels through various interactions. The study demonstrates that the critical transition temperature (Tcloud) of MF can be modulated, and the hydrogel maintains its gel morphology over the tested temperature range. The gelation of MF only occurs when the temperature is above the Tcloud, with macroscopic aggregates forming in the sol state due to LCST behavior transforming into the three-dimensional structures of the hydrogel. This research highlights the unique role of LCST behavior in the formation of supramolecular hydrogels and provides insights into the design of thermo-sensitive supramolecular systems.
The research describes the construction of a complex supramolecular structure known as a hetero[3]rotaxane through a process called integrative self-sorting. The purpose of this study was to demonstrate how different subunits could be integrated into a single complex with precise positional control, mimicking nature's efficient use of noncovalent self-assembly and self-sorting phenomena. The researchers used two very similar crown ethers, benzo-21-crown-7 (C7) and dibenzo-24-crown-8 (C8), along with two components, 1-H·PF6 and 2-H·PF6, to create a four-component self-sorting system. They then integrated these into a divalent counterpart, 3-2H·2PF6, which has two binding sites. The study concluded that through integrative self-sorting, a well-organized hetero[3]rotaxane structure was successfully constructed, with C7 and C8 binding almost quantitatively to sites A and B, respectively, on the axle 3-2H·2PF6. The researchers also synthesized a "cascade-stoppered" hetero[3]rotaxane, 5-2H·2PF6, which was shown to be highly stable against dethreading of one of the wheels. This research highlights the potential of integrative self-sorting as a programming language in nature for constructing complex supramolecular assemblies and artificial smart materials with well-organized structures and functions.
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