Technology Process of L-Glutamic acid, N-[2,5-difluoro-4-(2-propynylamino)benzoyl]-, diethyl
ester
There total 6 articles about L-Glutamic acid, N-[2,5-difluoro-4-(2-propynylamino)benzoyl]-, diethyl
ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
N,N-dimethyl-formamide; toluene;
at 100 ℃;
for 5h;
DOI:10.1021/jm00090a024
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 78 percent / fuming HNO3 / 0.5 h / 0 - 10 °C
2: 85 percent / Na2Cr2O7, AcOH, conc. H2SO4
3: oxalyl chloride, DMF / CH2Cl2 / 2.5 h
4: 100 percent / Et3N / CH2Cl2 / 1 h
5: 85 percent / Fe, AcOH / 2 h / 50 °C
6: 34 percent / K2CO3 / dimethylformamide; toluene / 5 h / 100 °C
With
sodium dichromate; oxalyl dichloride; sulfuric acid; nitric acid; iron; potassium carbonate; acetic acid; triethylamine; N,N-dimethyl-formamide;
In
dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00090a024
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 85 percent / Na2Cr2O7, AcOH, conc. H2SO4
2: oxalyl chloride, DMF / CH2Cl2 / 2.5 h
3: 100 percent / Et3N / CH2Cl2 / 1 h
4: 85 percent / Fe, AcOH / 2 h / 50 °C
5: 34 percent / K2CO3 / dimethylformamide; toluene / 5 h / 100 °C
With
sodium dichromate; oxalyl dichloride; sulfuric acid; iron; potassium carbonate; acetic acid; triethylamine; N,N-dimethyl-formamide;
In
dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00090a024