452-67-5

Usage

Chemical Properties

colorless to light yellow liqui

InChI:InChI=1/C7H6FI/c1-5-4-6(9)2-3-7(5)8/h2-4H,1H3

Upstream product

• 455-88-9 5-nitro-2-fluorotoluene 
• 95-52-3 2-Fluorotoluene 
• 352-70-5 m-Fluorotoluene 
• 108-88-3 toluene 
• 31463-45-3 1,4,7,7,8,8-Hexafluor-2-methylbicyclo<2,2,2>octa-2,5-dien 

Downstream Products

• 495-07-8 2,5-difluorobenzyl chloride 
• 2646-90-4 2,5-difluorobenzaldehyde 
• 141412-60-4 1,4-difluoro-2-methyl-5-nitrobenzene 
• 85117-99-3 2-(bromomethyl)-1,4-difluorobenzene 
• 101155-09-3 6-chloro-9-(2,5-difluorobenzyl)-9H-purine 
• 59541-83-2 5-fluoro-2-phenyl-1H-indole 
• 95-52-3 2-Fluorotoluene 
• 1116681-97-0 2-(2,5-Difluoro-4-methylphenyl)-4,4,5,5-tetramethyl[1,3,2]dioxaborolane 
• 932374-58-8 tert-butyl 4-[(4-fluoro-5-methyl-2-nitrophenyl)amine]piperidine-1-carboxylate 
• 932374-49-7 tert-butyl 4-([2-amino-4-fluoro-5-methylphenyl]amino)piperidine-1-carboxylate 
• 932374-51-1 1,1-dimethylethyl 4-(5-fluoro-6-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidine-carboxylate 
• 1380302-53-3 1,4-difluoro-6-(2-phenylethenyl)-benzo[c]phenanthrene 
• 1380302-49-7 (E/Z)-2-[1-methyl-2-(2,5-difluorophenyl)ethenyl]-naphthalene 
• 1380302-55-5 Br^(1-)*C₃₇H₂₆F₂P⁽¹⁺⁾ 

Relevant academic research and scientific papers

Reactions of aromatic compounds with xenon difluoride

Reactions of substituted benzenes C6H5R (R = Me, F, Cl, Br, CF3, NO2) with xenon difluoride in the presence of boron trifluoride–diethyl ether complex in weakly acidic (1,1,1,3,3-pentafluorobutane) and weakly basic media (acetonitrile) have been studied. These reactions lead to the formation of fluorobenzene derivatives FC6H4R (isomer mixture) together with isomeric difluorobenzenes and fluorinated and non-fluorinated biphenyls. The results have been compared with previously reported data obtained in other solvents using other catalysts.

Competitive fluorination on methyl-group and benzene-ring during the anodic fluorination of fluorotoluenes in Et4NF · mHF

Electrochemical fluorinations of 2-fluorotoluene (2a), 3-fluorotoluene (3a) and 4-fluorotoluene (4a) in neat Et4NF · mHF (Et = C2H5, m = 3.5 or 4.0) were carried out on a platinum anode. The fluorination of 2a, 3a and 4a occurred competitively both on the side-chain (formation of monofluoromethylfluorobenzenes) and on the benzene-ring (formation of methyltrifluoro-1,4-cyclohexadienes). These results are explained by the facility of proton elimination from the methyl groups of the radical cations which have been formed by the anodic one-electron transfer reactions of 2a, 3a and 4a. A cyclic voltammogram of 4a showed three anodic current peaks which correspond to the oxidation of 4a, 1-fluoromethyl-4-fluorobenzene (4b) and 1-difluoromethyl-4-fluorolbenzene (4c). On the other hand, voltammograms of 2a and 3a showed two anodic current peaks and no difluoromethylfluorobenzenes was obtained during the fluorination of 2a and 3a.