Technology Process of 4-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,
3-mercapto-7-methoxy-8-oxo-, (4-nitrophenyl)methyl ester, trans-
There total 6 articles about 4-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,
3-mercapto-7-methoxy-8-oxo-, (4-nitrophenyl)methyl ester, trans- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: MgSO4 / CH2Cl2 / 1 h
2: 18 percent / Et3N, 4 Angstroem mol. sieves / CH2Cl2 / 5 h / -78 - 25 °C
3: 1.) O3, 4 Angstroem mol. sieves, 2.) Me2S / 1.) CH2Cl2, MeOH, -78 deg C, 2.) CH2Cl2, MeOH, from -78 to 25 deg C, 18 h
4: 60 percent / sodium cyanoborohydride, bromocresol green, 10percent aq. HCl / tetrahydrofuran; ethanol / 3.5 h
5: 69 percent / pyridine / 18 h / -5 - 0 °C
6: 1.) LHMDS, 2.) CS2 / 1.) THF, -78 deg C, 15 min, 2.) THF, from -78 deg C to RT, 18 h
With
pyridine; hydrogenchloride; carbon disulfide; dimethylsulfide; 4 A molecular sieve; bromocresol green; sodium cyanoborohydride; magnesium sulfate; ozone; triethylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; ethanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 60 percent / sodium cyanoborohydride, bromocresol green, 10percent aq. HCl / tetrahydrofuran; ethanol / 3.5 h
2: 69 percent / pyridine / 18 h / -5 - 0 °C
3: 1.) LHMDS, 2.) CS2 / 1.) THF, -78 deg C, 15 min, 2.) THF, from -78 deg C to RT, 18 h
With
pyridine; hydrogenchloride; carbon disulfide; bromocresol green; sodium cyanoborohydride; lithium hexamethyldisilazane;
In
tetrahydrofuran; ethanol;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 18 percent / Et3N, 4 Angstroem mol. sieves / CH2Cl2 / 5 h / -78 - 25 °C
2: 1.) O3, 4 Angstroem mol. sieves, 2.) Me2S / 1.) CH2Cl2, MeOH, -78 deg C, 2.) CH2Cl2, MeOH, from -78 to 25 deg C, 18 h
3: 60 percent / sodium cyanoborohydride, bromocresol green, 10percent aq. HCl / tetrahydrofuran; ethanol / 3.5 h
4: 69 percent / pyridine / 18 h / -5 - 0 °C
5: 1.) LHMDS, 2.) CS2 / 1.) THF, -78 deg C, 15 min, 2.) THF, from -78 deg C to RT, 18 h
With
pyridine; hydrogenchloride; carbon disulfide; dimethylsulfide; 4 A molecular sieve; bromocresol green; sodium cyanoborohydride; ozone; triethylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; ethanol; dichloromethane;
