3-Amino-4-benzyloxyphenyl acetate

Base Information

• Chemical Name: 3-Amino-4-benzyloxyphenyl acetate
• CAS No.: 141498-80-8
• Molecular Formula: C15H15NO3
• Molecular Weight: 257.28400
• DSSTox Substance ID: DTXSID101251649
• Mol file: 141498-80-8.mol

Synonyms:3-aMino-4-benzyloxylphenylacetate;141498-80-8;3-amino-4-benzyloxyphenyl acetate;(3-amino-4-phenylmethoxyphenyl) acetate;Phenol, 3-amino-4-(phenylmethoxy)-, 1-acetate;SCHEMBL3290591;4-benzyloxy-3-aminophenyl acetate;KQFVAFIKSQFLBX-UHFFFAOYSA-N;DTXSID101251649;AM90180;FT-0696017

Chemical Property of 3-Amino-4-benzyloxyphenyl acetate

Chemical Property:

• PSA: 61.55000
• LogP: 3.35430
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 257.10519334
• Heavy Atom Count: 19
• Complexity: 289

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)OC1=CC(=C(C=C1)OCC2=CC=CC=C2)N

Technology Process of 3-Amino-4-benzyloxyphenyl acetate

There total 3 articles about 3-Amino-4-benzyloxyphenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

3-nitro-4-benzyloxy-phenyl acetate (141498-79-5) → 3-amino-4-benzyloxyphenyl acetate (141498-80-8)

Guidance literature:

With hydrogen; platinum(IV) oxide; In methanol; for 7h; Ambient temperature;

DOI:10.1080/00397919208021110

Reference yield:

4-Benzyloxyphenol (103-16-2) → 3-amino-4-benzyloxyphenyl acetate (141498-80-8)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid / 24 h / Heating

2: HNO₃ / acetic acid / 1 h / 50 - 60 °C

3: 70 percent / H₂ / PtO₂ / methanol / 7 h / Ambient temperature

With hydrogen; nitric acid; platinum(IV) oxide; In methanol; acetic acid;

DOI:10.1080/00397919208021110

Reference yield:

4-(benzyloxy)phenyl acetate (6311-66-6) → 3-amino-4-benzyloxyphenyl acetate (141498-80-8)

Guidance literature:

Multi-step reaction with 2 steps

1: HNO₃ / acetic acid / 1 h / 50 - 60 °C

2: 70 percent / H₂ / PtO₂ / methanol / 7 h / Ambient temperature

With hydrogen; nitric acid; platinum(IV) oxide; In methanol; acetic acid;

DOI:10.1080/00397919208021110

upstream raw materials:

3-nitro-4-benzyloxy-phenyl acetate

4-Benzyloxyphenol

4-(benzyloxy)phenyl acetate

Downstream raw materials:

(3-Acetylamino-4-benzyloxy-1-acetoxy)-benzene

4-benzyloxy-3-(N-methylsulphonylamino)-phenyl acetate

4-benzyloxy-3-propanesulfonylamino-benzene acetate

4-Benzyloxy-3-(phenylsulphonylamino)phenyl acetate

Refernces