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103-16-2

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Product FOB Price Min.Order Supply Ability Supplier
Monobenzone cream/monobenzone powder/monobenzone whitening cream
Cas No: 103-16-2
USD $ 345.0-354.0 / Kilogram 5 Kilogram 100000 Gram/Year Xi'an Quanao Biotech Co., Ltd. Contact Supplier
Monobenzone Raw Material Monobenzone 99% Powder 103-16-2
Cas No: 103-16-2
USD $ 185.0-195.0 / Kilogram 1 Kilogram 20000 Kilogram/Month Shaanxi Yuantai Biological Technology Co., Ltd. Contact Supplier
Professional supply Monobenzone cas 103-16-2
Cas No: 103-16-2
No Data 1 Kilogram 10 Metric Ton/Month Hangzhou Sartort Biopharma Co., Ltd Contact Supplier
Monobenzone powder 4-Benzyloxyphenol (PBP)
Cas No: 103-16-2
USD $ 12.0-12.0 / Gram 10 Gram 200 Metric Ton/Year Jinan Finer Chemical Co., Ltd Contact Supplier
Benzyl Hydro Quinone Wholesale Price in Stock Factory Supply Pbp CAS 103-16-2
Cas No: 103-16-2
USD $ 10.0-10.0 / Kilogram 1 Kilogram 1 Metric Ton/Day Hebei Qianglong Technology import and export Co, LTD Contact Supplier
Hydroquinone monobenzyl ether
Cas No: 103-16-2
No Data No Data 1 Metric Ton/Week Wuhan ZeShanCheng Biomedical Technology Co., Ltd. Contact Supplier
4-Benzyloxyphenol Manufacturer/High quality/Best price/In stock
Cas No: 103-16-2
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
Cosmetic grade 99% up High Purity 4-Benzyloxyphenol Monobenzone / PBP
Cas No: 103-16-2
USD $ 150.0-150.0 / Kilogram 25 Kilogram 50000 Kilogram/Month Sinoway Industrial Co., Ltd. Contact Supplier
High quality 4-Benzyloxy Phenol (Monobenzone) supplier in China
Cas No: 103-16-2
No Data 1 Metric Ton 30 Metric Ton/Month Simagchem Corporation Contact Supplier
High purity 103-16-2 PBP
Cas No: 103-16-2
USD $ 100.0-500.0 / Gram 1 Gram 99999 Gram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier

103-16-2 Usage

Definition

ChEBI: The monobenzyl ether of hydroquinone. It is used as a topical drug for medical depigmentation.

Uses

Hydroquinone monobenzyl ether is an antidegradant added to rubber products; inhibitor in acrylic resins.

Abstract

Monobenzone, also called 4-(Benzyloxy)phenol and monobenzyl ether of hydroquinone (MBEH) is an organic chemical in the phenol family with chemical formula C6H5CH2OC6H4OH. It is used as a topical drug for medical depigmentation. Monobenzone occurs as a white, almost tasteless crystalline powder, soluble in alcohol and practically insoluble in water. The topical application of monobenzone in animals, increases the excretion of melanin from the melanocytes. The same action is thought to be responsible for the depigmenting effect of the drug in humans.

References

http://www.medicinenet.com/monobenzone-topical/article.htm https://www.drugs.com/pro/benoquin.html http://www.emedicinehealth.com/drug-monobenzone_topical/article_em.htm#important

Chemical Properties

cream to beige-light brownish crystals or

How to use

This medication is for use on the skin only. Apply a thin layer of the medication to normal-colored skin, usually 2-3 times daily or as directed by your doctor. Avoid getting this product in your eyes or on the inside of your nose or mouth. If you do get this medication in those areas, flush with plenty of water.After using this medication, the skin will be permanently affected and sensitive to sunlight. Avoid prolonged exposure to sunlight, tanning booths, and sunlamps. Always use a sunscreen of SPF 15 or greater, and wear protective clothing when outdoors.It may take up to 4 months before the full benefit of this drug takes effect. Once the desired skin color is achieved, this medication is applied only as needed to maintain your new skin color (usually 2 times a week).Use this medication regularly to get the most benefit from it. To help you remember, use it at the same times each day.Inform your doctor if your condition persists or worsens after 4 months. You should not use this medication if you are allergic to monobenzone. Do not use monobenzone on any areas that are not affected by vitiligo.

Stimulate data

Skin-guinea pigs 5%/48 hours,? mild grade.

Uses

PBP is used as antiinflammatory, antisecretory, antiulcer.

Extinguishing agent

Dry powder, foam, sand, carbon dioxide, mist water.

Treatment for vitiligo

Monobenzone may cause destruction of melanocytes and permanent depigmentation.Hyperpigmented skin appears to fade more rapidly than does normal skin, and exposure to sunlight reduces the depigmenting effect of the drug. The histology of the skin after depigmentation with topical monobenzone is the same as that seen in vitiligo; the epidermis is normal except for the absence of identifiable melanocytes.This function enables it treat the uneven appearance of the skin due to a loss of skin color (vitiligo). It works by permanently removing color from normal skin located around skin with vitiligo. This will help to make the appearance of the skin more even.? What calls for special attention is that: Do not use this drug to treat other skin discoloration problems ("sun spots," "age spots," freckles, skin discoloration caused by hormone medicine, perfumes, pregnancy, or skin trauma). Monobenzone is not a mild cosmetic bleach. Because it causes a permanent discoloration of the skin, it may not be the right treatment for these other skin conditions. Besides, Monobenzone is also being considered for the treatment of Melanoma.

Category

Toxic substance

Indications

Monobenzone (Benoquin) potently inhibits melanin production and destroys melanocytes. Like hydroquinone, monobenzone was originally introduced for the topical treatment of disorders of excess melanin pigmentation, including melasma. It is now used only to permanently depigment the remaining normally pigmented skin in patients with extensive vitiligo. Irritant and allergic contact dermatitis are common side effects.

Storage

Ventilated warehouse, low temperature, dry; Separated from food raw materials.

Purification Methods

Crystallise it from EtOH or H2O, and dry (P2O5) under vacuum. [Walter et al. J Am Chem Soc 108 5210 1986, Beilstein 6 IV 5778.]

Synthesis Reference(s)

Tetrahedron Letters, 33, p. 5129, 1992 DOI: 10.1016/S0040-4039(00)61209-1

Flammability hazard characteristics

The drug is combustible, and combustion releases stimulus smoke.

Acute toxicity

Abdomen-rat LD50: 4500 mg/kg

Brand name

Benoquin (Valeant).

Toxic grading

Moderate toxicity

Description

May cause depigmentation
InChI:InChI=1/C14H14O.C6H6O2/c1-3-7-13(8-4-1)11-15-12-14-9-5-2-6-10-14;7-5-1-2-6(8)4-3-5/h1-10H,11-12H2;1-4,7-8H

103-16-2 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Alfa Aesar (A14843)  4-Benzyloxyphenol, 98+%    103-16-2 25g 366.0CNY Detail
Alfa Aesar (A14843)  4-Benzyloxyphenol, 98+%    103-16-2 50g 623.0CNY Detail
Alfa Aesar (A14843)  4-Benzyloxyphenol, 98+%    103-16-2 100g 1018.0CNY Detail
Alfa Aesar (A14843)  4-Benzyloxyphenol, 98+%    103-16-2 250g 2163.0CNY Detail
Alfa Aesar (A14843)  4-Benzyloxyphenol, 98+%    103-16-2 1000g 7119.0CNY Detail
USP (1445506)  Monobenzone  United States Pharmacopeia (USP) Reference Standard 103-16-2 1445506-200MG 4,588.74CNY Detail

103-16-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name monobenzone

1.2 Other means of identification

Product number -
Other names 4-Benzyloxyphenol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:103-16-2 SDS

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