2,5-Dihydro-2,3-dimethyl-1,2,4-benzothiadiazepine 1,1-dioxide

Base Information

Chemical Name:2,5-Dihydro-2,3-dimethyl-1,2,4-benzothiadiazepine 1,1-dioxide
CAS No.:46377-45-1
Molecular Formula:C10H12N2O2S
Molecular Weight:224.2795
Hs Code.:
Mol file:46377-45-1.mol

Synonyms:2,5-Dihydro-2,3-dimethyl-1,2,4-benzothiadiazepine 1,1-dioxide;1,2,4-Benzothiadiazepine,2,5-dihydro-2,3-dimethyl-,1,1-dioxide;2,3-dimethyl-5H-1;

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,5-Dihydro-2,3-dimethyl-1,2,4-benzothiadiazepine 1,1-dioxide

Chemical Property:

Vapor Pressure:9E-06mmHg at 25°C
Boiling Point:373.4°Cat760mmHg
PKA:-0.11±0.20(Predicted)
Flash Point:179.6°C
PSA：58.12000
Density:1.31g/cm³
LogP:1.69340

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2,5-Dihydro-2,3-dimethyl-1,2,4-benzothiadiazepine 1,1-dioxide

There total 3 articles about 2,5-Dihydro-2,3-dimethyl-1,2,4-benzothiadiazepine 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 93612-39-6
3-methyl-4,5-dihydro-1,2,4-benzothiadiazepine-1,1-dioxide

: 74-88-4
methyl iodide

: 46377-45-1
2,3-dimethyl-4,5-dihydro-1,2,4-benzothiadiazepine-1,1-dioxide

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1016/S0040-4020(01)85933-0

Reference yield:

: 40431-37-6
2-(bromomethyl)-N-methylbenzenesulfonamide

: 75-05-8,26809-02-9
acetonitrile

: 46377-45-1
2,3-dimethyl-4,5-dihydro-1,2,4-benzothiadiazepine-1,1-dioxide

Guidance literature:: With tin(IV) chloride; at 120 - 140 ℃;
DOI:10.1021/jm00279a003

Reference yield:

: 88-19-7
methyl 2-(aminosulfonyl)benzoate

: 46377-45-1
2,3-dimethyl-4,5-dihydro-1,2,4-benzothiadiazepine-1,1-dioxide

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / 1M LiClO₄, HClO₄ / Ambient temperature; electrochemical process

2: 68 percent / NaH / dimethylformamide / Ambient temperature

With perchloric acid; lithium perchlorate; sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)85933-0