Technology Process of 1H-Imidazole-1-carbothioic acid,
O-[4-(methylenecyclopropyl)-2,2-diphenylbutyl] ester
There total 8 articles about 1H-Imidazole-1-carbothioic acid,
O-[4-(methylenecyclopropyl)-2,2-diphenylbutyl] ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: lithium aluminium hydride / diethyl ether / 24 h / Heating
2: 77 percent / p-TsOH / CH2Cl2 / 36 h / Heating
3: 78 percent / n-BuLi / hexane; diethyl ether / -35 - 25 °C
4: 95 percent / potassium tert-butoxide / dimethylsulfoxide / 1 h / 70 °C
5: 85 percent / p-TsOH / methanol / 3 h / 50 °C
6: 95 percent / tetrahydrofuran / 2 h / Heating
With
lithium aluminium tetrahydride; n-butyllithium; potassium tert-butylate; toluene-4-sulfonic acid;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/S0040-4020(01)89429-1
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 78 percent / n-BuLi / hexane; diethyl ether / -35 - 25 °C
2: 95 percent / potassium tert-butoxide / dimethylsulfoxide / 1 h / 70 °C
3: 85 percent / p-TsOH / methanol / 3 h / 50 °C
4: 95 percent / tetrahydrofuran / 2 h / Heating
With
n-butyllithium; potassium tert-butylate; toluene-4-sulfonic acid;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dimethyl sulfoxide;
DOI:10.1016/S0040-4020(01)89429-1