2,6-Pyridinedicarboxaldehyde

Base Information

• Chemical Name: 2,6-Pyridinedicarboxaldehyde
• CAS No.: 5431-44-7
• Molecular Formula: C7H5NO2
• Molecular Weight: 135.122
• Hs Code.: 29333990
• European Community (EC) Number: 226-589-6
• NSC Number: 13393
• UNII: FX6E2354Y8
• DSSTox Substance ID: DTXSID80202681
• Nikkaji Number: J28.016J
• Wikipedia: 2,6-Diformylpyridine
• Wikidata: Q72503875
• Mol file: 5431-44-7.mol

Synonyms:2,6-diformylpyridine

Chemical Property of 2,6-Pyridinedicarboxaldehyde

Chemical Property:

• Appearance/Colour: white to tan powder or crystals
• Vapor Pressure: 0.107mmHg at 25°C
• Melting Point: 122 °C
• Refractive Index: 1.632
• Boiling Point: 221.4 °C at 760 mmHg
• PKA: 1.84±0.10(Predicted)
• Flash Point: 102.8 °C
• PSA: 47.03000
• Density: 1.274 g/cm³
• LogP: 0.70660
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 135.032028402
• Heavy Atom Count: 10
• Complexity: 122

Purity/Quality:

98% ^*data from raw suppliers

2,6-Pyridinedicarboxaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC(=C1)C=O)C=O
• Uses: 2,6-Pyridinedicarboxaldehyde is an intermediate used to prepare functionalized resin Amberlite XAD-4,?boron-dipyrromethene (BODIPY)-based fluorescence probe with a N,N′-(pyridine-2, 6-diylbis(methylene))-dianiline substituent and novel N-heterocyclic chitosan aerogel derivatives. 2,6-Pyridinedicarboxaldehyde has been used in preparation of:functionalized resin Amberlite XAD-4boron-dipyrromethene (BODIPY)-based fluorescence probe with a N,N′-(pyridine-2, 6-diylbis(methylene))-dianiline substituent novel N-heterocyclic chitosan aerogel derivatives

Technology Process of 2,6-Pyridinedicarboxaldehyde

There total 25 articles about 2,6-Pyridinedicarboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2.6-bis(hydroxymethyl)pyridine (1195-59-1) → 2,6-Pyridinedicarboxaldehyde (5431-44-7)

Guidance literature:

With selenium(IV) oxide; In 1,4-dioxane; for 2h; Reflux;

Reference yield: 98.0%

2,6-dibenzylidene-pyridine (10129-71-2) → 2,6-Pyridinedicarboxaldehyde (5431-44-7)

Guidance literature:

With ozone; In methanol; dichloromethane; at -70 - 20 ℃; for 0.5h;

2,6-dibenzylidene-pyridine; With tricyanoethylphosphine; In methanol; dichloromethane; at 20 ℃;

DOI:10.1081/SCC-200032468

Reference yield: 95.0%

2,6-bis-(bromomethyl)pyridine (7703-74-4) → 2,6-Pyridinedicarboxaldehyde (5431-44-7)

Guidance literature:

With dimethyl selenoxide; In 1,2-dichloro-ethane; for 4h; Heating;

DOI:10.1055/s-1984-30956

upstream raw materials:

6-methyl-2-pyridinecarboxaldehyde

2,6-Dibromopyridine

isopropylmagnesium chloride

N,N-dimethyl-formamide

Downstream raw materials:

2,6-bis-[bis-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-methyl]-pyridine

pyridine-2,6-dicarbaldehyde-bis thiosemicarbazone

(1E,1'E)-1,1'-(pyridine-2,6-diyl)bis(N-phenylmethanimine)

2,6-bis-(1,3-diphenyl-imidazolidin-2-yl)-pyridine