N-Carbethoxy-4-piperidone

Base Information

Chemical Name:N-Carbethoxy-4-piperidone
CAS No.:29976-53-2
Molecular Formula:C8H13NO3
Molecular Weight:171.196
Hs Code.:29333999
European Community (EC) Number:249-984-5
NSC Number:139022
UNII:7H5JX1S259
DSSTox Substance ID:DTXSID0057704
Nikkaji Number:J27.978A
Wikidata:Q27268281
Mol file:29976-53-2.mol

Synonyms:N-Carbethoxy-4-piperidone;29976-53-2;Ethyl 4-oxopiperidine-1-carboxylate;Ethyl 4-oxo-1-piperidinecarboxylate;N-Carboethoxy-4-piperidone;1-Ethoxycarbonyl-4-piperidone;1-Carbethoxy-4-piperidone;1-Piperidinecarboxylic acid, 4-oxo-, ethyl ester;4-Oxo-1-piperidinecarboxylic acid ethyl ester;1-(Ethoxycarbonyl)-4-piperidone;MFCD00006188;N-Ethoxycarbonyl-4-piperidone;1-Ethoxycarbonyl-4-piperidinone;1-Ethoxycarbonyl-4-oxopiperidine;UNII-7H5JX1S259;N-Ethoxycarbonyl-4-piperidinone;DTXSID0057704;7H5JX1S259;EINECS 249-984-5;NSC-139022;4-oxo-piperidine-1-carboxylic acid ethyl ester;N-Carbethoxy-4-piperidon;ethyl 4-oxopiperidinecarboxylate;Loratadine impurity H;1-carboethoxy-4-piperidone;n-carbethoxy-4-piperidinone;1-carbethoxypiperidin-4-one;SCHEMBL158497;DTXCID8031493;Ethyl 4-Piperidone-N-carboxylate;BCP23114;HY-Y0217;Tox21_113793;NSC139022;STL183271;ethyl 4-oxo-piperidine-1-carboxylate;AKOS000119559;GS-3033;NSC 139022;1-(CARBOETHOXY)-4-PIPERIDINONE;NCGC00253669-01;Ethyl 4-oxo-1-piperidinecarboxylate, 98%;CAS-29976-53-2;LORATADINE IMPURITY H [EP IMPURITY];A5543;AM20090403;CS-0008473;E0403;FT-0607567;4-Oxopiperidine-1-carboxylic acid ethyl ester;EN300-15626;SR-01000944742;SR-01000944742-1;W-106965;Q27268281;Z33618657;F1908-0061;ethyl 4-oxopiperidine-1-carboxylate;ethyl4-oxopiperidine-1-carboxylate;Loratadine impurity H, European Pharmacopoeia (EP) Reference Standard

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of N-Carbethoxy-4-piperidone

Chemical Property:

Appearance/Colour:Clear colorless to pale yellow colored liquid
Vapor Pressure:0.00574mmHg at 25°C
Refractive Index:n20/D 1.475(lit.)
Boiling Point:273.4 °C at 760 mmHg
PKA:-1.59±0.20(Predicted)
Flash Point:87.8 °C
PSA：46.61000
Density:1.155 g/cm³
LogP:0.74570
Storage Temp.:2-8°C
Solubility.:Chloroform (Slightly), Methanol (Slightly)
Water Solubility.:slightly soluble
XLogP3:-0.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:171.08954328
Heavy Atom Count:12
Complexity:181

Purity/Quality:

Safty Information:

Pictogram(s): Xn, Xi
Hazard Codes:Xn,Xi
Statements: 36/38-22-36/37/38-20/21/22
Safety Statements: 23-24/25-37/39-26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)N1CCC(=O)CC1
Uses N-Carbethoxy-4-piperidone is used in the preparation of 3-hydrazinopyridazines as antihypertensive agents as well as γ-carboline derivatives as potential serotonergic agents. N-Carbethoxy-4-piperidone is also an Impurity of Loratadine (L469575). N-Carbethoxy-4-piperidone (Loratadine EP Impurity H) is used in the preparation of 3-hydrazinopyridazines as antihypertensive agents as well as γ-carboline derivatives as potential serotonergic agents. N-Carbethoxy-4-piperidone is also an impurity of Loratadine (L469575). Ethyl 4-oxo-1-piperidinecarboxylate (1-carbethoxy-4-piperidone) was used to prepare tertiary alcohols.

Technology Process of N-Carbethoxy-4-piperidone

There total 13 articles about N-Carbethoxy-4-piperidone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.2%