1H-Imidazole-5-carboxylic acid, 2-butyl-4-chloro-1-[[4-[2-(1H-tetrazol-5-yl)-1-cyclohexen-1-yl]phenyl]meth yl]-

Base Information

• Chemical Name: 1H-Imidazole-5-carboxylic acid, 2-butyl-4-chloro-1-[[4-[2-(1H-tetrazol-5-yl)-1-cyclohexen-1-yl]phenyl]meth yl]-
• CAS No.: 141754-26-9
• Molecular Formula: C₂₂H₂₅ClN₆O₂
• Molecular Weight: 440.933
• Mol file: 141754-26-9.mol

Synonyms:

Chemical Property of 1H-Imidazole-5-carboxylic acid, 2-butyl-4-chloro-1-[[4-[2-(1H-tetrazol-5-yl)-1-cyclohexen-1-yl]phenyl]meth yl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Imidazole-5-carboxylic acid, 2-butyl-4-chloro-1-[[4-[2-(1H-tetrazol-5-yl)-1-cyclohexen-1-yl]phenyl]meth yl]-

There total 11 articles about 1H-Imidazole-5-carboxylic acid, 2-butyl-4-chloro-1-[[4-[2-(1H-tetrazol-5-yl)-1-cyclohexen-1-yl]phenyl]meth yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-cyanocyclohexanone (4513-77-3) → 2-Butyl-5-chloro-3-{4-[2-(2H-tetrazol-5-yl)-cyclohex-1-enyl]-benzyl}-3H-imidazole-4-carboxylic acid (141754-26-9)

Guidance literature:

Multi-step reaction with 9 steps

1: 75 percent / diisopropylethylamine / 1,2-dichloro-ethane / 2 h / 0 °C

2: 80 percent / palladium tetrakis(triphenylphosphine), LiCl / dioxane / 16 h / Heating

3: 100 percent / NaBH₄ / ethanol; CH₂Cl₂ / 2.5 h / 0 °C

4: 87 percent / carbon tetrabromide, triphenyl phosphine / acetonitrile / 20 h / 10 °C

5: 1.) NaH / 1.) DMF, 0 deg C, 2.) DMF, 0 deg C, 1.5 h

6: 89 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 0 °C

7: 80 percent / manganese dioxide / 1,2-dichloro-ethane / 8 h / Irradiation

8: 87 percent / NaClO₄, NaH₂PO₄ / H₂O; 2-methyl-propan-2-ol; various solvent(s) / 16 h / Ambient temperature

9: 1.) tributyltin azide, 2.) HCl / 1.) 80 deg C, 5 d, 2.) Et₂O, 10 min

With hydrogenchloride; manganese(IV) oxide; sodium tetrahydroborate; sodium dihydrogenphosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tributyltin azide; carbon tetrabromide; sodium perchlorate; tetrabutyl ammonium fluoride; sodium hydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium chloride; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; 1,2-dichloro-ethane; acetonitrile; tert-butyl alcohol;

DOI:10.1021/jm00092a017

Reference yield:

2-n-butyl-4-chloro-5-hydroxymethylimidazole (79047-41-9) → 2-Butyl-5-chloro-3-{4-[2-(2H-tetrazol-5-yl)-cyclohex-1-enyl]-benzyl}-3H-imidazole-4-carboxylic acid (141754-26-9)

Guidance literature:

Multi-step reaction with 6 steps

1: 80 percent / imidazole / dimethylformamide / 3.5 h / Ambient temperature

2: 1.) NaH / 1.) DMF, 0 deg C, 2.) DMF, 0 deg C, 1.5 h

3: 89 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 0 °C

4: 80 percent / manganese dioxide / 1,2-dichloro-ethane / 8 h / Irradiation

5: 87 percent / NaClO₄, NaH₂PO₄ / H₂O; 2-methyl-propan-2-ol; various solvent(s) / 16 h / Ambient temperature

6: 1.) tributyltin azide, 2.) HCl / 1.) 80 deg C, 5 d, 2.) Et₂O, 10 min

With 1H-imidazole; hydrogenchloride; manganese(IV) oxide; sodium dihydrogenphosphate; tributyltin azide; sodium perchlorate; tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1021/jm00092a017

Reference yield:

2-(4-formylphenyl)-1-cyclohexene-1-carbonitrile (141754-32-7) → 2-Butyl-5-chloro-3-{4-[2-(2H-tetrazol-5-yl)-cyclohex-1-enyl]-benzyl}-3H-imidazole-4-carboxylic acid (141754-26-9)

Guidance literature:

Multi-step reaction with 7 steps

1: 100 percent / NaBH₄ / ethanol; CH₂Cl₂ / 2.5 h / 0 °C

2: 87 percent / carbon tetrabromide, triphenyl phosphine / acetonitrile / 20 h / 10 °C

3: 1.) NaH / 1.) DMF, 0 deg C, 2.) DMF, 0 deg C, 1.5 h

4: 89 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 0 °C

5: 80 percent / manganese dioxide / 1,2-dichloro-ethane / 8 h / Irradiation

6: 87 percent / NaClO₄, NaH₂PO₄ / H₂O; 2-methyl-propan-2-ol; various solvent(s) / 16 h / Ambient temperature

7: 1.) tributyltin azide, 2.) HCl / 1.) 80 deg C, 5 d, 2.) Et₂O, 10 min

With hydrogenchloride; manganese(IV) oxide; sodium tetrahydroborate; sodium dihydrogenphosphate; tributyltin azide; carbon tetrabromide; sodium perchlorate; tetrabutyl ammonium fluoride; sodium hydride; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane; water; 1,2-dichloro-ethane; acetonitrile; tert-butyl alcohol;

DOI:10.1021/jm00092a017

upstream raw materials:

2-butyl-4-chloro-1-<<4-(2-cyano-1-cyclohexen-1-yl)phenyl>methyl>-1H-imidazole-5-carboxylic acid

2-cyanocyclohexanone

2-n-butyl-4-chloro-5-hydroxymethylimidazole

2-(4-formylphenyl)-1-cyclohexene-1-carbonitrile