Antibiotic 66-40D

Base Information

Chemical Name:Antibiotic 66-40D
CAS No.:53759-50-5
Molecular Formula:C₁₈H₃₅N₅O₇
Molecular Weight:433.505
Hs Code.:
DSSTox Substance ID:DTXSID60968531
Mol file:53759-50-5.mol

Synonyms:Antibiotic 66-40D;Sisomicin-B;53759-50-5;6640B;66-40D;D-Streptamine, O-3-deoxy-3-(methylamino)-alpha-D-xylopyranosyl-(1-6)-O-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-glycero-hex-4-enopyranosyl-(1-4))-2-deoxy-;C18H35N5O7;C18-H35-N5-O7;53797-16-3;C18H35N5O7.H2O;DTXSID60968531;D-Streptamine, O-3-deoxy-3-(methylamino)-.alpha.-D-xylopyranosyl-(1.fwdarw.6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-.alpha.-D-glycero-hex-4-enopyranosyl-(1.fwdarw.4)]-2-deoxy-;C18-H35-N5-O7.H2-O;LS-20997;LS-146999;4,6-Diamino-3-{[3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-3-(methylamino)pentopyranoside;D-Streptamine, O-3-deoxy-3-(methylamino)-.beta.-L-arabinopyranosyl-(1.fwdarw.6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-.alpha.-D-glycero-hex-4-enopyranosyl-(1.fwdarw.4)]-2-deoxy-

Suppliers and Price of Antibiotic 66-40D

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
SISOMICIN D 95.00%
5MG
$ 499.29

Total 1 raw suppliers

Chemical Property of Antibiotic 66-40D

Chemical Property:

Vapor Pressure:1.39E-21mmHg at 25°C
Boiling Point:682.7°Cat760mmHg
Flash Point:366.7°C
PSA：213.72000
Density:1.41g/cm³
LogP:-1.04950
XLogP3:-5.3
Hydrogen Bond Donor Count:8
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:6
Exact Mass:433.25364847
Heavy Atom Count:30
Complexity:599

Purity/Quality:

95% ^*data from raw suppliers

SISOMICIN D 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CNC1C(COC(C1O)OC2C(CC(C(C2O)OC3C(CC=C(O3)CN)N)N)N)O

Technology Process of Antibiotic 66-40D

There total 6 articles about Antibiotic 66-40D which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (3aR,7R,7aR)-6-[(1S,2S,3R,4S,6R)-4,6-Diamino-3-((2S,3R)-3-amino-6-aminomethyl-3,4-dihydro-2H-pyran-2-yloxy)-2-hydroxy-cyclohexyloxy]-7-hydroxy-1-methyl-hexahydro-pyrano[4,3-d]oxazol-2-one

: 53759-50-5,53797-16-3,77881-75-5
Sisomicin D

Guidance literature:: With barium dihydroxide; at 80 - 90 ℃; for 1h; Yield given;
DOI:10.1002/cber.19811140303

Reference yield:

: 77852-44-9,77881-72-2
6-O-<2-O-Benzyl-3-N,4-O-carbonyl-3-desoxy-3-(methylamino)-L-arabinopyranosyl>-tetrakis-N-(benzyloxycarbonyl)sisamin

: 53759-50-5,53797-16-3,77881-75-5
Sisomicin D

Guidance literature:: Multi-step reaction with 2 steps

1: Na, NH₃ liq. / tetrahydrofuran / 1 h

2: Ba(OH)2 / 1 h / 80 - 90 °C

With barium dihydroxide; ammonia; sodium; In tetrahydrofuran;
DOI:10.1002/cber.19811140303

Reference yield:

: 40147-35-1,78085-61-7,78085-62-8,79298-79-6,79298-80-9
1-O-Acetyl-2,4-di-O-benzyl-3-desoxy-3-(N-methylacetamido)-L-arabinopyranose

: 53759-50-5,53797-16-3,77881-75-5
Sisomicin D

Guidance literature:: Multi-step reaction with 3 steps

1: Me₃SiCl / toluene; benzene-d6; tetradeuteriomethanol / 0.75 h / 45 - 50 °C / waterbath

2: 1) Ag₂CO₃, AgClO₄, drierite / 1) THF, 2 h, 2) THF, 30 min

3: 1) Na, NH₃ liq., 2) Ba(OH)2

With calcium sulfate; barium dihydroxide; chloro-trimethyl-silane; ammonia; silver perchlorate; sodium; silver carbonate; In d⁽⁴⁾-methanol; benzene-d6; toluene;
DOI:10.1002/cber.19811140303