2-(1-Oxo-1,3-dihydro-2H-isoindol-2-yl)propanoic acid

Base Information

• Chemical Name: 2-(1-Oxo-1,3-dihydro-2H-isoindol-2-yl)propanoic acid
• CAS No.: 67266-14-2
• Molecular Formula: C11H10NO3-
• Molecular Weight: 205.213
• Hs Code.: 2918300090
• DSSTox Substance ID: DTXSID60377422
• ChEMBL ID: CHEMBL1611947
• Mol file: 67266-14-2.mol

Synonyms:67266-14-2;2-(1-oxoisoindolin-2-yl)propanoic acid;2-(1-Oxo-1,3-dihydro-2H-isoindol-2-yl)propanoic acid;2-(3-oxo-1H-isoindol-2-yl)propanoic acid;2-(1-Oxo-1,3-dihydro-2H-isoindol-2-yl)-propanoic acid;2-(1-oxo-2,3-dihydro-1H-isoindol-2-yl)propanoic acid;MLS-0315756.0001;Bionet2_000988;Oprea1_673439;SCHEMBL2013546;CHEMBL1611947;BDBM43782;cid_2764373;DTXSID60377422;XBPWPQBDGZFHQI-UHFFFAOYSA-N;HMS1366M20;MFCD00664643;STK915723;AKOS002846338;AKOS016143003;2-(1-oxoisoindolin-2-yl)propanoicacid;CCG-202961;SB64316;2-(1-ketoisoindolin-2-yl)propionic acid;CS-0272252;FT-0680645;8L-017;EN300-297579;A867308;2-(3-oxidanylidene-1H-isoindol-2-yl)propanoic acid;J-505400;2-(1-Oxo-1,3-dihydro-isoindol-2-yl)-propionic acid;2-(1-OXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)PROPANOICACID

Chemical Property of 2-(1-Oxo-1,3-dihydro-2H-isoindol-2-yl)propanoic acid

Chemical Property:

• Vapor Pressure: 3.27E-08mmHg at 25°C
• Melting Point: 202-204oC
• Boiling Point: 431.5°Cat760mmHg
• Flash Point: 214.8°C
• PSA: 57.61000
• Density: 1.342g/cm³
• LogP: 1.05340
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 205.07389321
• Heavy Atom Count: 15
• Complexity: 290

Purity/Quality:

97% ^*data from raw suppliers

(2S)-2-(1-oxo-2,3-dihydro-1H-isoindol-2-yl)propanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(=O)O)N1CC2=CC=CC=C2C1=O

Technology Process of 2-(1-Oxo-1,3-dihydro-2H-isoindol-2-yl)propanoic acid

There total 3 articles about 2-(1-Oxo-1,3-dihydro-2H-isoindol-2-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

rac-Ala-OH (302-72-7,25191-17-7,18875-37-1) + o-phthalic dicarboxaldehyde (643-79-8) → 2,3-dihydro-1-oxo-1H-isoindole-2-(α-methyl)acetic acid (67266-14-2)

Guidance literature:

With acetic acid; for 0.166667h; Heating;

DOI:10.1039/c39850001183

Reference yield:

methyl 2-bromomethylbenzoate (2417-73-4) + DL-alanine ethyl ester hydrochloride (617-27-6) → 2,3-dihydro-1-oxo-1H-isoindole-2-(α-methyl)acetic acid (67266-14-2)

Guidance literature:

With sodium hydroxide; triethylamine; Yield given. Multistep reaction; 1.) methanol, reflux, 36 h 2.) 100 deg C, 30 min;

Reference yield:

→ 2,3-dihydro-1-oxo-1H-isoindole-2-(α-methyl)acetic acid (67266-14-2)

Guidance literature:

Phthalimidalanin (19), Zn, in AcOH, Pd/C;

upstream raw materials:

methyl 2-bromomethylbenzoate

DL-alanine ethyl ester hydrochloride

rac-Ala-OH

o-phthalic dicarboxaldehyde